TY - JOUR
T1 - Infections as risk factor of Sjögren’s syndrome
AU - Utomo, Suyud Warno
AU - Putri, Jemima Fajarin
N1 - Publisher Copyright:
© 2020 Utomo and Putri.
PY - 2020
Y1 - 2020
N2 - Purpose: Sjögren’s syndrome (SS) is an autoimmune disease targeting exocrine glands, leading to low body fluids production, especially on the salivary and lacrimal glands. Due to the low saliva and tear production, the common symptoms of Sjögren’s syndrome are dry eyes and dry mouth, later on leading to uncomfortable sensations on the eye surface, cornea destruction, dental caries, and oral cavity infections. Several infections are known to cause similar side-effects to Sjögren’s syndrome symptoms, including low saliva flow; therefore, infection is hypothesized as one of the risk factors of Sjögren’s syndrome. Results: Based on our literature research, there are several infectious agents which cause similar disease manifestations to Sjögren’s syndrome, including infections of hepatitis C virus, Epstein–Barr virus, cytomegalovirus, and human T-lymphotropic virus-1 (HTLV-1), and these four agents are found to cause persistent infection on the salivary gland after the first infection and later lead to organ destruction, thus causing sicca syndrome in the oral cavity. Other findings show possible Heliobacter pylori infection might lead on the increasing level of anti-Ro/SSA and anti-La/SSB of infected individuals. Conclusion: Some research has shown persistent infection could trigger autoimmune disorders due to continuous T-cells and B-cells activation in an attempt of infected cells eradication, leading to autoimmune reaction and high autoreactive cells concentration around the healthy cells causing the immune cells to eradicate the healthy cells nearby. However, the results in this literature study found persistent infection is not the only risk factor of Sjögren’s syndrome but there are various unknown factors that trigger infection to develop into Sjögren’s syndrome.
AB - Purpose: Sjögren’s syndrome (SS) is an autoimmune disease targeting exocrine glands, leading to low body fluids production, especially on the salivary and lacrimal glands. Due to the low saliva and tear production, the common symptoms of Sjögren’s syndrome are dry eyes and dry mouth, later on leading to uncomfortable sensations on the eye surface, cornea destruction, dental caries, and oral cavity infections. Several infections are known to cause similar side-effects to Sjögren’s syndrome symptoms, including low saliva flow; therefore, infection is hypothesized as one of the risk factors of Sjögren’s syndrome. Results: Based on our literature research, there are several infectious agents which cause similar disease manifestations to Sjögren’s syndrome, including infections of hepatitis C virus, Epstein–Barr virus, cytomegalovirus, and human T-lymphotropic virus-1 (HTLV-1), and these four agents are found to cause persistent infection on the salivary gland after the first infection and later lead to organ destruction, thus causing sicca syndrome in the oral cavity. Other findings show possible Heliobacter pylori infection might lead on the increasing level of anti-Ro/SSA and anti-La/SSB of infected individuals. Conclusion: Some research has shown persistent infection could trigger autoimmune disorders due to continuous T-cells and B-cells activation in an attempt of infected cells eradication, leading to autoimmune reaction and high autoreactive cells concentration around the healthy cells causing the immune cells to eradicate the healthy cells nearby. However, the results in this literature study found persistent infection is not the only risk factor of Sjögren’s syndrome but there are various unknown factors that trigger infection to develop into Sjögren’s syndrome.
KW - Autoimmune diseases
KW - Infections
KW - Pathogens
KW - Sjögren’s syndrome
UR - http://www.scopus.com/inward/record.url?scp=85096810291&partnerID=8YFLogxK
U2 - 10.2147/OARRR.S276727
DO - 10.2147/OARRR.S276727
M3 - Review article
AN - SCOPUS:85096810291
SN - 1179-156X
VL - 12
SP - 257
EP - 266
JO - Open Access Rheumatology: Research and Reviews
JF - Open Access Rheumatology: Research and Reviews
ER -