TY - JOUR
T1 - Infection with soil-transmitted helminths is associated with increased insulin sensitivity
AU - Wiria, Aprilianto E.
AU - Hamid, Firdaus
AU - Wammes, Linda J.
AU - Prasetyani, Margaretta A.
AU - Dekkers, Olaf M.
AU - May, Linda
AU - Kaisar, Maria M.M.
AU - Verweij, Jaco J.
AU - Guigas, Bruno
AU - Partono, Felix
AU - Sartono, Erliyani
AU - Supali, Taniawati
AU - Yazdanbakhsh, Maria
AU - Smit, Johannes W.A.
N1 - Publisher Copyright:
© 2015 Wiria et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2015/6/10
Y1 - 2015/6/10
N2 - Objective: Given that helminth infections have been shown to improve insulin sensitivity in animal studies, which may be explained by beneficial effects on energy balance or by a shift in the immune system to an anti-inflammatory profile, we investigated whether soil-transmitted helminth (STH)-infected subjects are more insulin sensitive than STH-uninfected subjects. Design: We performed a cross-sectional study on Flores island, Indonesia, an area with high prevalence of STH infections. Methods: From 646 adults, stool samples were screened for Trichuris trichiura by microscopy and for Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, and Strongyloides stercoralis by qPCR. No other helminth was found. We collected data on body mass index (BMI, kg/m2), waist-to-hip ratio (WHR), fasting blood glucose (FBG, mmol/L), insulin (pmol/L), high sensitive C-reactive protein (ng/ml) and Immunoglobulin E (IU/ml). The homeostatic model assessment for insulin resistance (HOMAIR) was calculated and regression models were used to assess the association between STH infection status and insulin resistance. Results: 424 (66%) participants had at least one STH infection. STH infected participants had lower BMI (23.2 vs 22.5 kg/m2, p value = 0.03) and lower HOMAIR (0.97 vs 0.81, p value = 0.05). In an age-, sex- and BMI-adjusted model a significant association was seen between the number of infections and HOMAIR: for every additional infection with STH species, the HOMAIR decreased by 0.10 (p for linear trend 0.01). This effect was mainly accounted for by a decrease in insulin of 4.9 pmol/L for every infection (p for trend = 0.07). Conclusion: STH infections are associated with a modest improvement of insulin sensitivity, which is not accounted for by STH effects on BMI alone.
AB - Objective: Given that helminth infections have been shown to improve insulin sensitivity in animal studies, which may be explained by beneficial effects on energy balance or by a shift in the immune system to an anti-inflammatory profile, we investigated whether soil-transmitted helminth (STH)-infected subjects are more insulin sensitive than STH-uninfected subjects. Design: We performed a cross-sectional study on Flores island, Indonesia, an area with high prevalence of STH infections. Methods: From 646 adults, stool samples were screened for Trichuris trichiura by microscopy and for Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, and Strongyloides stercoralis by qPCR. No other helminth was found. We collected data on body mass index (BMI, kg/m2), waist-to-hip ratio (WHR), fasting blood glucose (FBG, mmol/L), insulin (pmol/L), high sensitive C-reactive protein (ng/ml) and Immunoglobulin E (IU/ml). The homeostatic model assessment for insulin resistance (HOMAIR) was calculated and regression models were used to assess the association between STH infection status and insulin resistance. Results: 424 (66%) participants had at least one STH infection. STH infected participants had lower BMI (23.2 vs 22.5 kg/m2, p value = 0.03) and lower HOMAIR (0.97 vs 0.81, p value = 0.05). In an age-, sex- and BMI-adjusted model a significant association was seen between the number of infections and HOMAIR: for every additional infection with STH species, the HOMAIR decreased by 0.10 (p for linear trend 0.01). This effect was mainly accounted for by a decrease in insulin of 4.9 pmol/L for every infection (p for trend = 0.07). Conclusion: STH infections are associated with a modest improvement of insulin sensitivity, which is not accounted for by STH effects on BMI alone.
UR - http://www.scopus.com/inward/record.url?scp=84936818556&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0127746
DO - 10.1371/journal.pone.0127746
M3 - Article
C2 - 26061042
AN - SCOPUS:84936818556
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 6
M1 - e0127746
ER -