TY - JOUR

T1 - Indonesian prostate cancer risk calculator (IPCRC)

T2 - an application for predicting prostate cancer risk (a multicenter study)

AU - Yuri, Prahara

AU - Wangge, Grace

AU - Abshari, Fatan

AU - Satjakoesoemah, Adistra I.T.W.H.

AU - Perdana, Noor R.

AU - Wijaya, Candra D.K.

AU - Tansol, Christiano

AU - Tigor, Aaron

AU - Safriadi, Ferry

AU - Kadar, Dhiraya D.

AU - Warli, Syah M.

AU - Rochadi, Sungsang

AU - Danarto,

AU - Hakim, Lukman

AU - Djatisoesanto, Wahjoe

AU - Hardjowijoto, Sunaryo

AU - Mochtar, Chaidir Arif

AU - Umbas, H. Rainy

AU - Hamid, Agus Rizal Ardy Hariandy

PY - 2015/4/1

Y1 - 2015/4/1

N2 - AIM: to develop a prediction risk model of prostate cancer based on Indonesia population.METHODS: we included all benign prostate hyperthrophy (BPH) and PCa patients who had prostate biopsy and prostatectomy between January 2009 and December 2013 from 5 urology centers in Indonesia. The relationship between the possibility of PCa with the following variables including: age; PSA level, prostate volume (by transabdominal ultrasound or transrectal ultrasound) and digital rectal examination (DRE) finding. We calculated a predictive scoring equation to predict the possibility of PCa using chi-square analysis, Kolmogorov-Smirnov test, multiple logistic regression and ROC curve. Then, we designed an application for predicting prostate cancer risk called Indonesian Prostate Cancer Risk Calculator (IPCRC).RESULTS: there were 784 PCa and 1173 BPH patients were used for developing the risk calculator in our study. The mean ages, PSA and prostate volume are 66.9±8.1 years old; 72.4±248.9 ng/ml and 49.6±28.2 ml, respectively. Abnormal DRE was found in 637 PCa and 56 BPH. We included age, PSA level, abnormal DRE finding (all showed significant p<0.05 in univariate model). Additionally, although not significant, we included prostate volume (p=0.157) due to its clinical importance. The corrected ROC analysis showed AUC 0.935, sensitivity of 90.1% and specificity 80% in predicting the prostate cancer in our population.CONCLUSION: we have developed the Indonesian Prostate Cancer Risk Calculator which includes age, PSA, DRE, and prostate volume as its variables. Future prospective study to validate the risk calculator is needed.

AB - AIM: to develop a prediction risk model of prostate cancer based on Indonesia population.METHODS: we included all benign prostate hyperthrophy (BPH) and PCa patients who had prostate biopsy and prostatectomy between January 2009 and December 2013 from 5 urology centers in Indonesia. The relationship between the possibility of PCa with the following variables including: age; PSA level, prostate volume (by transabdominal ultrasound or transrectal ultrasound) and digital rectal examination (DRE) finding. We calculated a predictive scoring equation to predict the possibility of PCa using chi-square analysis, Kolmogorov-Smirnov test, multiple logistic regression and ROC curve. Then, we designed an application for predicting prostate cancer risk called Indonesian Prostate Cancer Risk Calculator (IPCRC).RESULTS: there were 784 PCa and 1173 BPH patients were used for developing the risk calculator in our study. The mean ages, PSA and prostate volume are 66.9±8.1 years old; 72.4±248.9 ng/ml and 49.6±28.2 ml, respectively. Abnormal DRE was found in 637 PCa and 56 BPH. We included age, PSA level, abnormal DRE finding (all showed significant p<0.05 in univariate model). Additionally, although not significant, we included prostate volume (p=0.157) due to its clinical importance. The corrected ROC analysis showed AUC 0.935, sensitivity of 90.1% and specificity 80% in predicting the prostate cancer in our population.CONCLUSION: we have developed the Indonesian Prostate Cancer Risk Calculator which includes age, PSA, DRE, and prostate volume as its variables. Future prospective study to validate the risk calculator is needed.

UR - http://www.scopus.com/inward/record.url?scp=84973424003&partnerID=8YFLogxK

M3 - Article

C2 - 26260551

AN - SCOPUS:84973424003

SN - 0125-9326

VL - 47

SP - 95

EP - 103

JO - Acta medica Indonesiana

JF - Acta medica Indonesiana

IS - 2

ER -