TY - JOUR
T1 - Indonesian Cinnamon (Cinnamomum burmannii)
T2 - Extraction, Flavonoid Content, Antioxidant Activity, and Stability in the Presence of Ascorbic Acid
AU - Rahayu, Dyah Utami Cahyaning
AU - Hakim, Regina Ainunnisa
AU - Mawarni, Shofi Airiza
AU - Satriani, Andhina Rizkya
N1 - Funding Information:
Funding: This research was carried out with financial support through a research collaboration grant between FMIPA UI and PT. Nose Herbalindo No. 002/NOSE/RND/PKS/V/2021 and/or 181/PKS/FMIPA/UI/2021.
Funding Information:
This research was carried out with financial support through a research collaboration grant between FMIPA UI and PT. Nose Herbalindo No. 002/NOSE/RND/PKS/V/2021 and/or 181/PKS/FMIPA/UI/2021.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6
Y1 - 2022/6
N2 - Cinnamon (Cinnamomum burmannii) is a potential source used in cosmetics to prevent skin aging due to its flavonoids and antioxidant properties. This research aims to determine the best solvent for extracting flavonoids, to conduct a large-scale isolation of flavonoids, and to evaluate the effect of ascorbic acid and temperature on the extract’s stability for 16 weeks. Various solvents for small-scale extraction were screened based on the polarity index, and one of the best for use in large-scale maceration was selected based on the AlCl3 colorimetric flavonoid content and DPPH antioxidant activity. The stability test was performed by treating cinnamon with and without ascorbic acid at selected temperatures. This test measured physical stability, evaluated flavonoid content and antioxidant activity, and analyzed volatile and non-volatile compounds using GC-MS and LC-MS. The most excellent solvent to extract flavonoids was ethanol due to its high yield (21.50%), flavonoid content (0.01749 ± 8.0 × 10−5 mg QE/g extract), and antioxidant activity (IC50 0.0162 + 7.5 × 10−4 mg/mL). The ascorbic acid addition at both temperatures affected the stability of the pH and chemical constituents. The vast majority of the extract’s flavonoid content and antioxidant activity continued to increase until the end of the observation week. This study revealed that ethanol was the best extraction solvent, and ascorbic acid can be recommended as a stabilizer of cinnamon extract for use in cosmetics for further application.
AB - Cinnamon (Cinnamomum burmannii) is a potential source used in cosmetics to prevent skin aging due to its flavonoids and antioxidant properties. This research aims to determine the best solvent for extracting flavonoids, to conduct a large-scale isolation of flavonoids, and to evaluate the effect of ascorbic acid and temperature on the extract’s stability for 16 weeks. Various solvents for small-scale extraction were screened based on the polarity index, and one of the best for use in large-scale maceration was selected based on the AlCl3 colorimetric flavonoid content and DPPH antioxidant activity. The stability test was performed by treating cinnamon with and without ascorbic acid at selected temperatures. This test measured physical stability, evaluated flavonoid content and antioxidant activity, and analyzed volatile and non-volatile compounds using GC-MS and LC-MS. The most excellent solvent to extract flavonoids was ethanol due to its high yield (21.50%), flavonoid content (0.01749 ± 8.0 × 10−5 mg QE/g extract), and antioxidant activity (IC50 0.0162 + 7.5 × 10−4 mg/mL). The ascorbic acid addition at both temperatures affected the stability of the pH and chemical constituents. The vast majority of the extract’s flavonoid content and antioxidant activity continued to increase until the end of the observation week. This study revealed that ethanol was the best extraction solvent, and ascorbic acid can be recommended as a stabilizer of cinnamon extract for use in cosmetics for further application.
KW - antioxidant
KW - ascorbic acid
KW - Cinnamomum burmannii
KW - cinnamon
KW - flavonoids
KW - stability
UR - http://www.scopus.com/inward/record.url?scp=85131797804&partnerID=8YFLogxK
U2 - 10.3390/cosmetics9030057
DO - 10.3390/cosmetics9030057
M3 - Article
AN - SCOPUS:85131797804
SN - 2079-9284
VL - 9
JO - Cosmetics
JF - Cosmetics
IS - 3
M1 - 57
ER -