Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

Henny Saraswati; Silvia Lee; Dino Tan; Evy Yunihastuti; Rino Gani; Patricia Price

doi:10.1016/j.humimm.2015.10.002

Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

Henny Saraswati, Silvia Lee, Dino Tan, Evy Yunihastuti, Rino Gani, Patricia Price

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Human Immunology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.humimm.2015.10.002
Publication status	Published - 1 Jan 2016

Keywords

Antiretroviral therapy
Dendritic cells
HCV
HIV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.humimm.2015.10.002

Cite this

@article{504250f145d7417ba0613cf7d9475025,

title = "Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART",

abstract = "Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.",

keywords = "Antiretroviral therapy, Dendritic cells, HCV, HIV",

author = "Henny Saraswati and Silvia Lee and Dino Tan and Evy Yunihastuti and Rino Gani and Patricia Price",

note = "Publisher Copyright: {\textcopyright} 2015 American Society for Histocompatibility and Immunogenetics.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.humimm.2015.10.002",

language = "English",

volume = "77",

pages = "29--34",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

AU - Saraswati, Henny

AU - Lee, Silvia

AU - Tan, Dino

AU - Yunihastuti, Evy

AU - Gani, Rino

AU - Price, Patricia

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

AB - Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

KW - Antiretroviral therapy

KW - Dendritic cells

KW - HCV

KW - HIV

UR - http://www.scopus.com/inward/record.url?scp=84951171891&partnerID=8YFLogxK

U2 - 10.1016/j.humimm.2015.10.002

DO - 10.1016/j.humimm.2015.10.002

M3 - Article

C2 - 26455474

AN - SCOPUS:84951171891

SN - 0198-8859

VL - 77

SP - 29

EP - 34

JO - Human Immunology

JF - Human Immunology

IS - 1

ER -

Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this