Increased Chromosomal Breaks in Lymphocytes of Ovarian Cancer Patients

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Abstract

Objective: To assess the increase in chromosomal breaks in lymphocytes of ovarian cancer patients, using micronucleus (MN) test, and to look for factors that might cause the breaks. Design: This is a descriptive study on ovarian cancer patients to gather data about histopathological findings, cell differentiation and staging, and to check whether there is a relationship between age and clastogen exposure with chromosomal breaks in lymphocytes. Setting: FMUI/Cipto Mangunkusumo Hospital, Jakarta. Materials and methods: Peripheral blood was obtained from 13 patients with ovarian cancer before chemotherapy, and processed for micronucleus counting. The MN count were compared between the group with age range ≤ 45 and > 45 using t test. The same was done between group with and without clastogen exposure. To check whether there was a co-existence of certain histopathological findings with breaks, we check every histopathological finding for the increase in chromosomal breaks Results: Eleven out of 13 subjects had an increase in MN count in lymphocytes, i.e. in patients with anaplastic, papillary and endometrioid adenocarcinoma. There was no significant difference in micronucleus count between groups. Conclusion: This study is the first to report that a majority of ovarian cancer patients had an increase in chromosomal breakage. Increased MN count in lymphocytes was suggested to be used as a marker of increased risk of metastasis in ovarian cancer.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalInternational Medical Journal
Volume10
Issue number4
Publication statusPublished - 1 Dec 2003

Keywords

  • Clastogen
  • Immune system and micronucleus test
  • Mutagen

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