Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

Tom Versteege, Mulya Rahma Karyanti, Witri Septiani, Annisa L. Widjanarko, Nikmah Salamia Idris, Aryono Hendarto, Diederick E. Grobbee, David Burgner, Cuno S.P.M. Uiterwaal, Patricia C.J.L. Bruijning-Verhagen

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.

Original languageEnglish
Pages (from-to)630-634
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume100
Issue number3
DOIs
Publication statusPublished - 1 Jan 2019

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