Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

Tom Versteege; Mulya R. Karyanti; Witri Septiani; Annisa L. Widjanarko; Nikmah S. Idris; Aryono Hendarto; Diederick E. Grobbee; David Burgner; Cuno S.P.M. Uiterwaal; Patricia C.J.L. Bruijning-Verhagen

doi:10.4269/ajtmh.18-0672

Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

Tom Versteege, Mulya R. Karyanti, Witri Septiani, Annisa L. Widjanarko, Nikmah S. Idris, Aryono Hendarto, Diederick E. Grobbee, David Burgner, Cuno S.P.M. Uiterwaal, Patricia C.J.L. Bruijning-Verhagen

Department of Pediatric

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.

Original language	English
Pages (from-to)	630-634
Number of pages	5
Journal	American Journal of Tropical Medicine and Hygiene
Volume	100
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.18-0672
Publication status	Published - 2019

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Versteege, T., Karyanti, M. R., Septiani, W., Widjanarko, A. L., Idris, N. S., Hendarto, A., Grobbee, D. E., Burgner, D., Uiterwaal, C. S. P. M., & Bruijning-Verhagen, P. C. J. L. (2019). Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene, 100(3), 630-634. https://doi.org/10.4269/ajtmh.18-0672

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title = "Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever",

abstract = "We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.",

author = "Tom Versteege and Karyanti, {Mulya R.} and Witri Septiani and Widjanarko, {Annisa L.} and Idris, {Nikmah S.} and Aryono Hendarto and Grobbee, {Diederick E.} and David Burgner and Uiterwaal, {Cuno S.P.M.} and Bruijning-Verhagen, {Patricia C.J.L.}",

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year = "2019",

doi = "10.4269/ajtmh.18-0672",

language = "English",

volume = "100",

pages = "630--634",

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Versteege, T, Karyanti, MR, Septiani, W, Widjanarko, AL, Idris, NS, Hendarto, A, Grobbee, DE, Burgner, D, Uiterwaal, CSPM & Bruijning-Verhagen, PCJL 2019, 'Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever', American Journal of Tropical Medicine and Hygiene, vol. 100, no. 3, pp. 630-634. https://doi.org/10.4269/ajtmh.18-0672

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T1 - Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

AU - Versteege, Tom

AU - Karyanti, Mulya R.

AU - Septiani, Witri

AU - Widjanarko, Annisa L.

AU - Idris, Nikmah S.

AU - Hendarto, Aryono

AU - Grobbee, Diederick E.

AU - Burgner, David

AU - Uiterwaal, Cuno S.P.M.

AU - Bruijning-Verhagen, Patricia C.J.L.

PY - 2019

Y1 - 2019

N2 - We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.

AB - We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.

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JF - American Journal of Tropical Medicine and Hygiene

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ER -

Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

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