TY - JOUR
T1 - Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever
AU - Versteege, Tom
AU - Karyanti, Mulya R.
AU - Septiani, Witri
AU - Widjanarko, Annisa L.
AU - Idris, Nikmah S.
AU - Hendarto, Aryono
AU - Grobbee, Diederick E.
AU - Burgner, David
AU - Uiterwaal, Cuno S.P.M.
AU - Bruijning-Verhagen, Patricia C.J.L.
N1 - Funding Information:
Disclaimer: T. V. reports grants from K. F. Hein Study Fund during the conduct of the study. M. K. reports grants from UMC Utrecht Developmental World Support grant during the conduct of the study. D. B. reports grants from National Health and Medical Research Council (Australia) during the conduct of the study.
Publisher Copyright:
Copyright © 2019 by The American Society of Tropical Medicine and Hygiene.
PY - 2019
Y1 - 2019
N2 - We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.
AB - We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.
UR - http://www.scopus.com/inward/record.url?scp=85062625171&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.18-0672
DO - 10.4269/ajtmh.18-0672
M3 - Article
C2 - 30675845
AN - SCOPUS:85062625171
VL - 100
SP - 630
EP - 634
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 3
ER -