TY - JOUR
T1 - Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever
AU - Versteege, Tom
AU - Karyanti, Mulya Rahma
AU - Septiani, Witri
AU - Widjanarko, Annisa L.
AU - Idris, Nikmah Salamia
AU - Hendarto, Aryono
AU - Grobbee, Diederick E.
AU - Burgner, David
AU - Uiterwaal, Cuno S.P.M.
AU - Bruijning-Verhagen, Patricia C.J.L.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.
AB - We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.
UR - http://www.scopus.com/inward/record.url?scp=85062625171&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.18-0672
DO - 10.4269/ajtmh.18-0672
M3 - Article
C2 - 30675845
AN - SCOPUS:85062625171
VL - 100
SP - 630
EP - 634
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 3
ER -