In vivo evaluation of luteolin-loaded phytosome

Cysilia K. Hindarto, Silvia Surini, Fadlina Chany Saputri, Candra Irawan

Research output: Contribution to journalArticlepeer-review


Luteolin exhibits antioxidant, antimicrobial, and antiinflammation activities. However, it shows poor oral bioavailability due to its low lipid-solubility. The aim of this study was to improve absorption of luteolin in the gastro-intestinal tract. Luteolin was formulated into luteolin-loaded phytosome (LLP) by thin film hydration method. In vivo evaluations were then performed to see plasma levels of luteolin in rats given oral LLP suspension and compared with those in the control group given pure luteolin suspension. Round-shaped LLPs were confirmed with average particle size 105.3 nm, PDI 0.735, zeta potential -34.4 mV, and entrapment efficiency 91.12%. In vivo studies showed a 3.54-fold increase in plasma level (AUC = 5426 µg.min/mL) of luteolin compared with those in control group. Phytosomes formulation successfully increased the absorption of luteolin hence it can serve as a promising delivery system for drugs with low lipids solubility
Original languageEnglish
Pages (from-to)347-349
JournalThe Pharma Innovation Journal
Issue number11
Publication statusPublished - 20 Oct 2017


  • Absorption, In vivo, Luteolin, Phytosome, Plasma concentration


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