TY - JOUR
T1 - In Vitro study of Garcinia celebica L. Stem Barks against Hepatitis C virus and Hepatocellular Carcinoma
AU - Apriyanto, D. R.
AU - Hartati, S.
AU - Dewi, B. E.
AU - Aoki-Utsubo, C.
AU - Hotta, H.
N1 - Publisher Copyright:
© 2019 Published under licence by IOP Publishing Ltd.
PY - 2019/10/25
Y1 - 2019/10/25
N2 - In this study, we are focused on Garcinia celebica as anti-HCV activity against JFH1 strain genotype 2a. The extraction process employed the use of maceration method. Starting from n-hexane solvent and another residue. The extracts were then analysed with various doses of 20, 10, 5, 2.5, and 1.25 μg/mL for anti-HCV against JFH1 strain genotype 2a and anticancer against Huh7it-1 cell line. The extracts exhibited anti-HCV on 1.25 μg/mL and no sign of toxicity to Huh7it-1 cells. The extracts also expressed anticancer activity on 20, 10, 5, and 2.5 μg/mL with a high level of toxicity to Huh7it-1 cells. The results from this study suggest that Garcinia celebica may be necessary as an add-on therapy candidate for treating HCV infections and HCC.
AB - In this study, we are focused on Garcinia celebica as anti-HCV activity against JFH1 strain genotype 2a. The extraction process employed the use of maceration method. Starting from n-hexane solvent and another residue. The extracts were then analysed with various doses of 20, 10, 5, 2.5, and 1.25 μg/mL for anti-HCV against JFH1 strain genotype 2a and anticancer against Huh7it-1 cell line. The extracts exhibited anti-HCV on 1.25 μg/mL and no sign of toxicity to Huh7it-1 cells. The extracts also expressed anticancer activity on 20, 10, 5, and 2.5 μg/mL with a high level of toxicity to Huh7it-1 cells. The results from this study suggest that Garcinia celebica may be necessary as an add-on therapy candidate for treating HCV infections and HCC.
UR - http://www.scopus.com/inward/record.url?scp=85075065125&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1360/1/012027
DO - 10.1088/1742-6596/1360/1/012027
M3 - Conference article
AN - SCOPUS:85075065125
SN - 1742-6588
VL - 1360
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012027
T2 - 1st International Symposium on Sciences, Engineering, and Technology, ISSET 2018
Y2 - 19 November 2018 through 20 November 2018
ER -
