In vitro release study of sambiloto (Andrographis paniculata) extract encapsulated by casein micelle as anti-diabetic herbal drug

Muhamad Sahlan, Katerina Evelyn, Diah Kartika Pratami, Kamarza Mulia

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Casein micelle as a biodegradable polymer has been used to encapsulate sambiloto (Andrographis paniculata) containing andrographolide compound as anti-diabetic herbal drug based on natural ingredients. Major obstacle of oral drug release system is gastrointestinal tracts in the body. Therefore, it is necessary to study release of sambiloto herbal drug to determine its accuracy which is expected can be sustained in the small intestine. In vitro release of this herbal drug had been studied by analyzing casein degradation in simulated gastric and intestinal fluid in presence of protease enzyme i.e, pepsin and pancreatin. In 2 hour simulated gastric fluid digestion (ratio substrate: enzyme optimum (w/w) 5:1), casein degradation tends to give a burst release profile in less than 30 minutes digestion. The presence of sambiloto in casein micelles slows casein degradation in simulated gastric fluid digestion. In 6 hours, the simulated intestinal fluid digestion (ratio substrate: enzyme optimum (w/w) 500:1), casein degradation tends to give a sustained release profile in about 4 hours digestion. Casein degradation profile tends to give burst release in first 30 minutes digestion in simulated intestinal fluid digestion when herbal drug was digested in simulated gastric - intestinal fluid.

Original languageEnglish
Title of host publicationProceedings of the 5th International Symposium on Applied Chemistry 2019
EditorsOsi Arutanti, Ahmad Randy, Muhammad Arifuddin Fitriady
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419223
DOIs
Publication statusPublished - 19 Nov 2019
Event5th International Symposium on Applied Chemistry 2019, ISAC 2019 - Bumi Serpong Dama (BSD) City, Tangerang, Indonesia
Duration: 23 Oct 201924 Oct 2019

Publication series

NameAIP Conference Proceedings
Volume2175
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium on Applied Chemistry 2019, ISAC 2019
CountryIndonesia
CityBumi Serpong Dama (BSD) City, Tangerang
Period23/10/1924/10/19

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