TY - JOUR
T1 - In vitro penetration activity of ionic liquid-Gnetum gnemon seed extract loaded solid lipid nanoparticles
AU - Trinovita, Elsa
AU - Rachmawati, Maesya
AU - Sutriyo, null
AU - Mun'im, Abdul
N1 - Funding Information:
This research was supported by the Ministry of Research and Technology, The Republic of Indonesia and the Directorate of Research and Community Service (DRPM), Universitas Indonesia through PITTA 2017.
Publisher Copyright:
© 2019 Elsa Trinovita et al.
PY - 2019/10
Y1 - 2019/10
N2 - Gnetum gnemon L. (Melinjo) seeds have high trans-resveratrol, which was known to have poor skin absorption ability. This study was performed to evaluate the skin absorption of ionic liquid-melinjo seed extract (IL-MSE) loaded solid lipid nanoparticles (SLN). The SLNs was formulated with glyceryl monostearate as the lipid ingredient, ceteareth-25, ceteareth-6, stearyl alcohol, an aqueous phase, and 10% melinjo seed extract. The SLNs were prepared by modification of high-pressure homogenization. The polydispersity index (PDI), zeta potential, entrapment efficiency (EE), particle size (PS), and morphological scanning electron microscopy (SEM) were evaluated. The in vitro penetration of IL-MSE SLN was carried out by using the Franz cell diffusion method. The SLNs formulations showed an average of particles size about 794 nm, and with high lipid and surfactant, the content could contributing to high entrapment efficiency to almost 89%. Even though the polydispersity index of SLN was 1.229, and zeta potential measurement was 62.56 mV. Up to 45% of the trans-resveratrol penetrated through the skin after 8 hours of the test run. The IL-MSE loaded to SLNs could improve the absorption of trans-resveratrol through the skin.
AB - Gnetum gnemon L. (Melinjo) seeds have high trans-resveratrol, which was known to have poor skin absorption ability. This study was performed to evaluate the skin absorption of ionic liquid-melinjo seed extract (IL-MSE) loaded solid lipid nanoparticles (SLN). The SLNs was formulated with glyceryl monostearate as the lipid ingredient, ceteareth-25, ceteareth-6, stearyl alcohol, an aqueous phase, and 10% melinjo seed extract. The SLNs were prepared by modification of high-pressure homogenization. The polydispersity index (PDI), zeta potential, entrapment efficiency (EE), particle size (PS), and morphological scanning electron microscopy (SEM) were evaluated. The in vitro penetration of IL-MSE SLN was carried out by using the Franz cell diffusion method. The SLNs formulations showed an average of particles size about 794 nm, and with high lipid and surfactant, the content could contributing to high entrapment efficiency to almost 89%. Even though the polydispersity index of SLN was 1.229, and zeta potential measurement was 62.56 mV. Up to 45% of the trans-resveratrol penetrated through the skin after 8 hours of the test run. The IL-MSE loaded to SLNs could improve the absorption of trans-resveratrol through the skin.
KW - Franz cell diffusion
KW - Gnetum gnemon
KW - Ionic liquid-melinjo seed extract
KW - Solid lipid nanoparticles
KW - Trans-resveratrol
UR - http://www.scopus.com/inward/record.url?scp=85081752389&partnerID=8YFLogxK
U2 - 10.7324/JAPS.2019.91002
DO - 10.7324/JAPS.2019.91002
M3 - Article
AN - SCOPUS:85081752389
SN - 2231-3354
VL - 9
SP - 9
EP - 16
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 10
ER -