In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone

Dhati Aulia Sari Junaidi; Emil Budianto

doi:10.1063/1.5082451

In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone

Dhati Aulia Sari Junaidi, Emil Budianto

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Captopril is an active oral inhibitor of angiotensin-converting enzyme (ACE) which has been widely used for hypertension and congestive heart failure treatment. Captopril has a short biological half-life and low bioavailability, so the drug must be taken repeatedly to obtain the expected therapeutic effect. Drug microencapsulation using biodegradable polymers is an alternative to minimalize these deficiencies. In this study, polyblend polylactic acid and polycaprolactone were used as a material that would encapsulate captopril. Microcapsules were made by the method of evaporating oil solvents in water using a tween 80 solution as an emulsifier. Variation of emulsion stirring speed and stirring time of dispersion. Both variations not positively affecting the increase of drug encapsulation.. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The optimum condition for microencapsulation was 60 PLA: 40 PCL with a concentration of tween 80 0.5% (state of dispersion of 900 rpm for 1 hour and the state of emulsion of 700 rpm for 1 hour) with an optimal encapsulation efficiency of 90.63%. The speed of emulsion mixing and the time of dispersion mixing did not significantly influence the efficiency of captopril microcapsule encapsulation.

Original language	English
Title of host publication	3rd International Seminar on Chemistry
Subtitle of host publication	Green Chemistry and Its Role for Sustainability
Editors	Fredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735417755
DOIs	https://doi.org/10.1063/1.5082451
Publication status	Published - 14 Dec 2018
Event	3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonesia Duration: 18 Jul 2018 → 19 Jul 2018

Publication series

Name	AIP Conference Proceedings
Volume	2049
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
Country/Territory	Indonesia
City	Surabaya
Period	18/07/18 → 19/07/18

Keywords

Microcapsules
captopril
drug delivery system
encapsulation
poly (lactic acid)
polyblend
polycaprolactone
tween 80

Access to Document

10.1063/1.5082451

Cite this

Junaidi, D. A. S., & Budianto, E. (2018). In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone. In F. Kurniawan, Y. Kusumawati, S. Fatmawati, H. Juwono, & A. S. Purnomo (Eds.), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability [020046] (AIP Conference Proceedings; Vol. 2049). American Institute of Physics Inc.. https://doi.org/10.1063/1.5082451

Junaidi, Dhati Aulia Sari ; Budianto, Emil. / In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone. 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. editor / Fredy Kurniawan ; Yuly Kusumawati ; Sri Fatmawati ; Hendro Juwono ; Adi Setyo Purnomo. American Institute of Physics Inc., 2018. (AIP Conference Proceedings).

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title = "In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone",

abstract = "Captopril is an active oral inhibitor of angiotensin-converting enzyme (ACE) which has been widely used for hypertension and congestive heart failure treatment. Captopril has a short biological half-life and low bioavailability, so the drug must be taken repeatedly to obtain the expected therapeutic effect. Drug microencapsulation using biodegradable polymers is an alternative to minimalize these deficiencies. In this study, polyblend polylactic acid and polycaprolactone were used as a material that would encapsulate captopril. Microcapsules were made by the method of evaporating oil solvents in water using a tween 80 solution as an emulsifier. Variation of emulsion stirring speed and stirring time of dispersion. Both variations not positively affecting the increase of drug encapsulation.. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The optimum condition for microencapsulation was 60 PLA: 40 PCL with a concentration of tween 80 0.5% (state of dispersion of 900 rpm for 1 hour and the state of emulsion of 700 rpm for 1 hour) with an optimal encapsulation efficiency of 90.63%. The speed of emulsion mixing and the time of dispersion mixing did not significantly influence the efficiency of captopril microcapsule encapsulation.",

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author = "Junaidi, {Dhati Aulia Sari} and Emil Budianto",

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Junaidi, DAS & Budianto, E 2018, In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone. in F Kurniawan, Y Kusumawati, S Fatmawati, H Juwono & AS Purnomo (eds), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability., 020046, AIP Conference Proceedings, vol. 2049, American Institute of Physics Inc., 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018, Surabaya, Indonesia, 18/07/18. https://doi.org/10.1063/1.5082451

In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone. / Junaidi, Dhati Aulia Sari; Budianto, Emil.
3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. ed. / Fredy Kurniawan; Yuly Kusumawati; Sri Fatmawati; Hendro Juwono; Adi Setyo Purnomo. American Institute of Physics Inc., 2018. 020046 (AIP Conference Proceedings; Vol. 2049).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone

AU - Junaidi, Dhati Aulia Sari

AU - Budianto, Emil

PY - 2018/12/14

Y1 - 2018/12/14

N2 - Captopril is an active oral inhibitor of angiotensin-converting enzyme (ACE) which has been widely used for hypertension and congestive heart failure treatment. Captopril has a short biological half-life and low bioavailability, so the drug must be taken repeatedly to obtain the expected therapeutic effect. Drug microencapsulation using biodegradable polymers is an alternative to minimalize these deficiencies. In this study, polyblend polylactic acid and polycaprolactone were used as a material that would encapsulate captopril. Microcapsules were made by the method of evaporating oil solvents in water using a tween 80 solution as an emulsifier. Variation of emulsion stirring speed and stirring time of dispersion. Both variations not positively affecting the increase of drug encapsulation.. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The optimum condition for microencapsulation was 60 PLA: 40 PCL with a concentration of tween 80 0.5% (state of dispersion of 900 rpm for 1 hour and the state of emulsion of 700 rpm for 1 hour) with an optimal encapsulation efficiency of 90.63%. The speed of emulsion mixing and the time of dispersion mixing did not significantly influence the efficiency of captopril microcapsule encapsulation.

AB - Captopril is an active oral inhibitor of angiotensin-converting enzyme (ACE) which has been widely used for hypertension and congestive heart failure treatment. Captopril has a short biological half-life and low bioavailability, so the drug must be taken repeatedly to obtain the expected therapeutic effect. Drug microencapsulation using biodegradable polymers is an alternative to minimalize these deficiencies. In this study, polyblend polylactic acid and polycaprolactone were used as a material that would encapsulate captopril. Microcapsules were made by the method of evaporating oil solvents in water using a tween 80 solution as an emulsifier. Variation of emulsion stirring speed and stirring time of dispersion. Both variations not positively affecting the increase of drug encapsulation.. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The optimum condition for microencapsulation was 60 PLA: 40 PCL with a concentration of tween 80 0.5% (state of dispersion of 900 rpm for 1 hour and the state of emulsion of 700 rpm for 1 hour) with an optimal encapsulation efficiency of 90.63%. The speed of emulsion mixing and the time of dispersion mixing did not significantly influence the efficiency of captopril microcapsule encapsulation.

KW - Microcapsules

KW - captopril

KW - drug delivery system

KW - encapsulation

KW - poly (lactic acid)

KW - polyblend

KW - polycaprolactone

KW - tween 80

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BT - 3rd International Seminar on Chemistry

A2 - Kurniawan, Fredy

A2 - Kusumawati, Yuly

A2 - Fatmawati, Sri

A2 - Juwono, Hendro

A2 - Purnomo, Adi Setyo

PB - American Institute of Physics Inc.

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Junaidi DAS, Budianto E. In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone. In Kurniawan F, Kusumawati Y, Fatmawati S, Juwono H, Purnomo AS, editors, 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. American Institute of Physics Inc. 2018. 020046. (AIP Conference Proceedings). doi: 10.1063/1.5082451

In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone

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