In vitro efficiency test of captopril microencapsulation using polyblend of poly (lactic acid) and polycaprolactone

Dhati Aulia Sari Junaidi, Emil Budianto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Captopril is an active oral inhibitor of angiotensin-converting enzyme (ACE) which has been widely used for hypertension and congestive heart failure treatment. Captopril has a short biological half-life and low bioavailability, so the drug must be taken repeatedly to obtain the expected therapeutic effect. Drug microencapsulation using biodegradable polymers is an alternative to minimalize these deficiencies. In this study, polyblend polylactic acid and polycaprolactone were used as a material that would encapsulate captopril. Microcapsules were made by the method of evaporating oil solvents in water using a tween 80 solution as an emulsifier. Variation of emulsion stirring speed and stirring time of dispersion. Both variations not positively affecting the increase of drug encapsulation.. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The optimum condition for microencapsulation was 60 PLA: 40 PCL with a concentration of tween 80 0.5% (state of dispersion of 900 rpm for 1 hour and the state of emulsion of 700 rpm for 1 hour) with an optimal encapsulation efficiency of 90.63%. The speed of emulsion mixing and the time of dispersion mixing did not significantly influence the efficiency of captopril microcapsule encapsulation.

Original languageEnglish
Title of host publication3rd International Seminar on Chemistry
Subtitle of host publicationGreen Chemistry and Its Role for Sustainability
EditorsFredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417755
DOIs
Publication statusPublished - 14 Dec 2018
Event3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonesia
Duration: 18 Jul 201819 Jul 2018

Publication series

NameAIP Conference Proceedings
Volume2049
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
CountryIndonesia
CitySurabaya
Period18/07/1819/07/18

Keywords

  • Microcapsules
  • captopril
  • drug delivery system
  • encapsulation
  • poly (lactic acid)
  • polyblend
  • polycaprolactone
  • tween 80

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