Captopril is an antihypertensive drug and is used for the treatment of congestive heart failure. Captopril has a short biological half-life and low bioavailability, and thus captopril must be taken repeatedly to get the desired therapeutic effect. Microcapsules are used as a drug delivery system that can cover the lack of captopril. In this research, polymer used for making microcapsules is biodegradable polymers, PDLA polymers with PCL use different mass composition variations to determine their effect on encapsulation efficiency and drug release percent, using Span 80 as surfactant and dichloromethane as solvent and solvent evaporation as the method. Characterization using FTIR, PSA, and optical microscopy on captopril microcapsules, then performed for an efficiency test, and dissolution test. The yield percent of microcapsules solids ranged from 98.52 % ± 0.95 to 97.51 % ± 0.95. The results of the PSA measurements obtained the average of the largest and smallest sizes, respectively were 0.546 μm ± 0.242 microcapsules PDLA:PCL 40:60 (w/w %), and 0.446 μm ± 0.123 in PDLA:PCL 10:90 (w/w %) microcapsules. The results of the optical microscope show that the microcapsules had a spherical shape and the surface has a hole. The efficiency encapsulation obtained was ranged between 17.21 % ± 4.37 to 35.62 % ± 0.47. In the dissolution test, microcapsules could hold the drug in the coating and release it slowly. The highest percent release in PDLA:PCL 10:90 (w/w %) microcapsules of 97.02 % and the lowest was in PDLA:PCL 40:60 (w/w %) microcapsules of 53.19 %. Captopril microcapsules could hold the drug in the matrix and release it slowly in dissolution test.