TY - GEN
T1 - In vitro and in silico study to evaluate the effectiveness of quercitrin as antiviral drug to dengue virus
AU - Dewi, Beti Ernawati
AU - Ratningpoeti, Edianti
AU - Desti, Hidayati
AU - Angelina, Marissa
N1 - Funding Information:
This study was supported by grant of Publikasi Terindeks Internasional untuk Tugas Akhir Mahasiswa Universitas Indonesia (PITTA) 2019 No: 0588/SK/R/UI/2019.
Publisher Copyright:
© 2019 Author(s).
PY - 2019/12/10
Y1 - 2019/12/10
N2 - Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 μg/ml, 38.8 μg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was -7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.
AB - Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 μg/ml, 38.8 μg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was -7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.
KW - DENV-2
KW - huh7 it-1 cell line
KW - in silico
KW - quercetrin
UR - http://www.scopus.com/inward/record.url?scp=85076734963&partnerID=8YFLogxK
U2 - 10.1063/1.5139341
DO - 10.1063/1.5139341
M3 - Conference contribution
AN - SCOPUS:85076734963
T3 - AIP Conference Proceedings
BT - 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
A2 - Lischer, Kenny
A2 - Abuzairi, Tomy
A2 - Rahman, Siti Fauziyah
A2 - Gozan, Misri
PB - American Institute of Physics Inc.
T2 - 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Y2 - 22 July 2019 through 24 July 2019
ER -
