In silico analysis of phytochemical compound found in snake fruit (Salacca zalacca) peel as anti-aging agent

Ermi Girsang, Chrismis Novalinda Ginting, I. Nyoman Ehrich Lister, Wahyu Widowati, Satrio Haryo Benowo Wibowo, Fajar Sukma Perdana, Rizal Rizal

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: Skin aging is a complicated natural phenomenon characterized by progressive loss of structural integrity and physiological function of the skin. Snake fruit (Salacca zalacca) is an important fruit crop native from Indonesia. Its waste is a potential source bioactive phytochemical compound. Objectives: Present study investigates possible anti-aging potency of phytochemical compound found in salak fruit peel based on its binding towards enzyme related in skin aging process. Materials and Methods: Molecular docking was performed towards enzyme subjected to degradation of dermal matrix (MMP1, NEP) and hyper-pigmentation (PPO3). Results: Docked compound occupied the active site of each protein in which chlorogenic acid has the highest affinity among salak peel compound against MMP1, and Rutin against NEP and PPO3. Further intermolecular analysis revealed favourable interaction between chlorogenic acid, rutin towards respective protein. Conclusions: Taken together compound found in snake fruit, display possible inhibition towards protein related in skin aging and could be potentially used as anti-aging agent.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalThai Journal of Pharmaceutical Sciences
Issue number2
Publication statusPublished - 2019


  • Aging
  • Molecular docking simulation
  • Phytochemicals
  • Salacca zalacca
  • Skin


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