TY - JOUR
T1 - In-depth analysis of lupeol
T2 - delving into the diverse pharmacological profile
AU - Dalimunthe, Aminah
AU - Carensia Gunawan, Mega
AU - Dhiya Utari, Zahirah
AU - Dinata, Muhammad Riza
AU - Halim, Princella
AU - Estherina S. Pakpahan, Nathasya
AU - Sitohang, Alex Insandus
AU - Sukarno, M. Andriansyah
AU - Yuandani,
AU - Harahap, Yahdiana
AU - Setyowati, Erna Prawita
AU - Park, Moon Nyeo
AU - Yusoff, Syaratul Dalina
AU - Zainalabidin, Satirah
AU - Prananda, Arya Tjipta
AU - Mahadi, Mohd Kaisan
AU - Kim, Bonglee
AU - Harahap, Urip
AU - Syahputra, Rony Abdi
N1 - Publisher Copyright:
Copyright © 2024 Dalimunthe, Carensia Gunawan, Dhiya Utari, Dinata, Halim, Estherina S. Pakpahan, Sitohang, Sukarno, Yuandani, Harahap, Setyowati, Park, Yusoff, Zainalabidin, Prananda, Mahadi, Kim, Harahap and Syahputra.
PY - 2024
Y1 - 2024
N2 - Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in various edible vegetables, fruits, and medicinal plants. Notably, it is found in high concentrations in plants like Tamarindus indica, Allanblackia monticola, and Emblica officinalis, among others. Quantitative studies have highlighted its presence in Elm bark, Olive fruit, Aloe leaf, Ginseng oil, Mango pulp, and Japanese Pear bark. This compound is synthesized from squalene through the mevalonate pathway and can also be synthetically produced in the lab, addressing challenges in natural product synthesis. Over the past four decades, extensive research has demonstrated lupeol’s multifaceted pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and antibacterial effects. Despite its significant therapeutic potential, clinical applications of lupeol have been limited by its poor water solubility and bioavailability. Recent advancements have focused on nano-based delivery systems to enhance its bioavailability, and the development of various lupeol derivatives has further amplified its bioactivity. This review provides a comprehensive overview of the latest advancements in understanding the pharmacological benefits of lupeol. It also discusses innovative strategies to improve its bioavailability, thereby enhancing its clinical efficacy. The aim is to consolidate current knowledge and stimulate further research into the therapeutic potential of lupeol and its derivatives.
AB - Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in various edible vegetables, fruits, and medicinal plants. Notably, it is found in high concentrations in plants like Tamarindus indica, Allanblackia monticola, and Emblica officinalis, among others. Quantitative studies have highlighted its presence in Elm bark, Olive fruit, Aloe leaf, Ginseng oil, Mango pulp, and Japanese Pear bark. This compound is synthesized from squalene through the mevalonate pathway and can also be synthetically produced in the lab, addressing challenges in natural product synthesis. Over the past four decades, extensive research has demonstrated lupeol’s multifaceted pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and antibacterial effects. Despite its significant therapeutic potential, clinical applications of lupeol have been limited by its poor water solubility and bioavailability. Recent advancements have focused on nano-based delivery systems to enhance its bioavailability, and the development of various lupeol derivatives has further amplified its bioactivity. This review provides a comprehensive overview of the latest advancements in understanding the pharmacological benefits of lupeol. It also discusses innovative strategies to improve its bioavailability, thereby enhancing its clinical efficacy. The aim is to consolidate current knowledge and stimulate further research into the therapeutic potential of lupeol and its derivatives.
KW - bioavailability
KW - lupeol
KW - nanotechnology
KW - pharmacological properties
KW - triterpenoids
UR - http://www.scopus.com/inward/record.url?scp=85210489461&partnerID=8YFLogxK
U2 - 10.3389/fphar.2024.1461478
DO - 10.3389/fphar.2024.1461478
M3 - Review article
AN - SCOPUS:85210489461
SN - 1663-9812
VL - 15
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 1461478
ER -