Pharmaceutical Industry has been crucial for national health and is one of the most growing industries in Indonesia. However, many problems occurred in this field, especially in drugs distribution routing. This paper conducts a study of drugs distribution routing comparison at one of the largest drug distributor company in Indonesia and has objective to get the best feasible solution for the company's decision basis of choosing daily distribution routing algorithm. The authors reach the objective by creating two-time scenarios (morning and afternoon) using Discrete Event Simulation (DES) to compare three algorithms using a heuristic approach: Sweeping, Nearest Neighbors, and Clark-Wright algorithms. This paper provides a novelty approach in drugs distribution routing problem by combining DES and heuristic approach to compare the VRP algorithm and develop the model using simulation software as a support decision. Based on the results from the model that the authors made, the authors obtained the best alternative as the result of algorithm comparison and discussed it with the expertise to find a robust solution before implementation.