Improvement of bone filler materials using granular calcium sulfate dihydrate-gelatin-polycaprolactone composite

Difa Putri Utami, Sunarso, Yosi Kusuma Eriwati, Siti Triaminingsih, Decky Joesiana Indrani, Dessy Innawaty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Calcium sulfate dihydrate (CSD) cement has been used as bone void filler and antibiotic carrier for many years. However, the main drawback of CSD cement is its brittleness that limits its handling property. The aim of this study is to fabricate granular CSD cement-gelatin-polycaprolactone (CSD-Gel-PCL) and evaluate its microstructure and mechanical behavior. To prepare CSD-Gel-PCL composite, granular CSD was prepared from calcium sulfate hemihydrate (CaSO4.0.5H2O; CSH) and distilled water with water/powder (W/P) ratio of 0.5. The CSD cement was crushed and sieved into 300-500 µm. The obtained granular CSD was then mixed with 3 wt.%, 5 wt.% and 7 wt.% gelatin solution which previously mixed with PCL (50 wt% PCL, 50 wt% gelatin), followed by freeze drying for 48 hours. The CSD granules were able to bind together after the addition of gelatin and PCL matrix. After freeze drying, the CSD granules were not easy to remove from the composite body. Scanning electron microscopy (SEM) analysis revealed that CSD granules were surrounded by polymer matrix in all 3 different specimens in which the higher gelatin concentration, the more the matrix found between the granules. Mechanical evaluation suggested that all of the specimens showed the same stress-strain curve pattern. The CSD-Gel-PCL composite with 7 wt% gelatin has the highest strength compared with the other specimens. Stress-strain curves indicated that combination of CSD granules, gelatin and PCL has produced bone filler with improved handling property.

Original languageEnglish
Title of host publicationAsian BioCeramics 18
EditorsArief Cahyanto, Arief Cahyanto, I Made Joni, I Made Joni
PublisherTrans Tech Publications Ltd
Pages63-68
Number of pages6
ISBN (Print)9783035714395
DOIs
Publication statusPublished - 1 Jan 2020
Event18th Asian BioCeramics Symposium, ABC 2018 - Bandung, Indonesia
Duration: 19 Sep 201820 Sep 2018

Publication series

NameKey Engineering Materials
Volume829 KEM
ISSN (Print)1013-9826

Conference

Conference18th Asian BioCeramics Symposium, ABC 2018
CountryIndonesia
CityBandung
Period19/09/1820/09/18

Keywords

  • Bone filler
  • Calcium sulfate dihydrate
  • Composite
  • Gelatin
  • Granular
  • Polycaprolactone

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    Utami, D. P., Sunarso, Eriwati, Y. K., Triaminingsih, S., Indrani, D. J., & Innawaty, D. (2020). Improvement of bone filler materials using granular calcium sulfate dihydrate-gelatin-polycaprolactone composite. In A. Cahyanto, A. Cahyanto, I. M. Joni, & I. M. Joni (Eds.), Asian BioCeramics 18 (pp. 63-68). (Key Engineering Materials; Vol. 829 KEM). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.829.63