Importance of Sclerostin as Bone-Muscle Mediator Crosstalk

I. Gusti Putu Suka Aryana, Sandra Surya Rini, Czeresna Heriawan Soejono

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Loss of bone and muscle mass is a frequent aging condition and has become a growing public health problem. The term “osteosarcopenia” denotes close links between bone and muscle. Mechanical exercise was once thought to be the only mechanism of crosstalk between muscle and bone. Sclerostin is an important player in the process of unloading-induced bone loss and plays an important role in mechanotransduction in the bone. Furthermore, bones and muscles are cat-egorized as endocrine organs because they produce hormone-like substances, resulting in “bone-muscle crosstalk.” Sclerostin, an inhibitor of bone development, has recently been shown to play a role in myogenesis. This review discusses the importance of sclerostin in bone-muscle crosstalk.

Original languageEnglish
Pages (from-to)72-82
Number of pages11
JournalAnnals of Geriatric Medicine and Research
Issue number2
Publication statusPublished - Jun 2022


  • Aging
  • Bone
  • Muscles
  • SOST protein


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