Implementation of multilinear regression in inhibition of thyroid hormone receptor-coactivator

A. S. Devi, D. Sarwinda, Gatot Fatwanto Hertono

Research output: Contribution to journalConference articlepeer-review

Abstract

Thyroid Hormone Receptors (TRs) play a big role in our body. Upon its nature TRs need coactivator to bind. MSNBAs had claimed to be the inhibitor of thyroid hormone receptor-coactivator interaction. Ninety-five targeted has been obtained by in vivo which classified to active and unspecified compounds. In this study, the active compounds will be tested ex vivo using multilinear regression method to explain the relationship of the physicochemical properties and biological activity - that is Quantitative Structure-Activity Relationship (QSAR) model and to show that the model is an analogue to the synthesis of MSNBAs. It appears that MSNBAs is fit to be an inhibitors of thyroid hormone receptor-coactivator with R-sq > 0,95.

Original languageEnglish
Article number012005
JournalJournal of Physics: Conference Series
Volume974
Issue number1
DOIs
Publication statusPublished - 22 Mar 2018
Event3rd International Conference on Mathematics: Pure, Applied and Computation, ICoMPAC 2017 - Surabaya, Indonesia
Duration: 1 Nov 20171 Nov 2017

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