@inproceedings{d0297e13c0a746a990403801af7caabd,
title = "Implementation of co-similarity measure on microarray data of lymphoma using K-means partition algorithm",
abstract = "Lymphoma is cancer of the lymphatic system that includes spleen, thymus, lymph nodes, bone marrow, and other parts of the body caused by lymphocytes cells. This study aims to implement the co-similarity measure in obtaining a non-overlapping significant bicluster in lymphoma gene expression data. Our proposed technique is based on χ -sim co-similarity measure for clustering row (gene) and column (condition). The process of biclustering is preceded by pre-processing using min-max normalization, applied co-similarity measure, partition each similarity matrix by using a k-means algorithm and extract bicluster. Furthermore, the silhouette method is used to determine the number of optimum clusters and measure the accuracy of grouping results. In our results, we obtained 2 clusters on the row (gene) similarity matrix and column (condition) similarity matrix with respectively silhouette value are 0.5464 and 0.7382. The clustering result consisted of 1242 genes (cluster-1) and 2784 genes (cluster-2) on the row (gene) similarity matrix and 41 conditions (cluster-1) and 21 conditions (cluster-2) on the column (condition) similarity matrix. Based on gene analysis that discovered genes in biclusters are supported by biological evidence and knowing the biological function of genes that significantly influence through gene ontology (GO) enrichment.",
keywords = "biclustering, co-similarity measure, gene expression, k-means, lymphoma",
author = "A. Bustamam and Puspa, {S. D.} and T. Siswantining",
note = "Funding Information: This research is supported by PITTA UI 2017 Grant from Universitas Indonesia with contract number 614. Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 ; Conference date: 26-07-2017 Through 27-07-2017",
year = "2018",
month = oct,
day = "22",
doi = "10.1063/1.5064219",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Ratna Yuniati and Terry Mart and Anggraningrum, {Ivandini T.} and Djoko Triyono and Sugeng, {Kiki A.}",
booktitle = "Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017",
}