Impacts of UC-MSCS on the Quality of Sperm in Asthenoteratozoospermia

Introduction: male infertility is caused by the condition of male partners, characterized by abnormal sperm shape and decreased motility, called asthenoteratozoospermia. Since active ingredients can regulate biological activity, secretory products from mesenchymal stem cells (MSCs) have recently become objects of interest as drugs. Method: the study hypothesis is that UC-MSC secretome impacts sperm quality in asthenoteratozoospermia-affected males depending on the parameters of sperm quality, antioxidant enzyme activity, and ROS concentration. The following sperm quality parameters were assessed, viability, intermotility, ultrastructure, SOD, 8OHdG, and catalase. Results: altogether, findings highlight that the stem MSC secretome isolated from the umbilical cord enhances the quality of sperm and will enhance fertility when applied in the process. It also decreases the concentration of biochemical markers of oxidative stress during the sperm preparation process. For example, it leads to a decrease in OHdG and an increase in SOD. Discussion: the results imply that MSC secretome may be an important therapeutic factor in reproductive health and reduced oxidative stress. According to the data, MSC secretome is likely an anti-oxidative treatment for enhancing the reproductive system.