TY - JOUR
T1 - Impact of the source of hematopoietic stem cells on immune reconstitution after transplantation
T2 - A systematic review
AU - Sugiyanto, Michael
AU - Gosal, Stephanie
AU - Kosim, Agatha
AU - Tahapary, Dicky Levenus
AU - Sianipar, Imelda Rosalyn
N1 - Funding Information:
This review was funded by the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia and The Indonesia Endowment Fund for Education (LPDP) through the Grant program year 2021. Riset Keilmuan
Publisher Copyright:
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Hematopoietic stem cell (HSC) transplantation's success lies in its ability to induce immune reconstitution. To date, there is no review published to compare the immune reconstitution among the three sources of HSC: umbilical cord blood (UCB), bone marrow (BM), and peripheral blood (PB). The review aims to analyze the kinetic of immune reconstitution among UCB, PB, and BM in HSC transplant patients by focusing on natural killer (NK) cells, B and T lymphocytes, and neutrophils. A systematic review was conducted through five databases, searching for clinical trials and randomized control trials (RCTs) which analyze the kinetics of immune reconstitution in at least two sources. Selected studies were assessed with Cochrane RoB 2.0. This review included 14 studies, with a total of 2539 subjects. The PB group achieved the fastest time to neutrophil recovery, while the B-cell count was the highest in the UCB group. The T-cell count is the lowest in the BM group, and the NK-cell count does not differ significantly among the three HSC sources. Among the three sources of HSC, there is no superior HSC source for any immune reconstitution parameter. More studies must be conducted to compare the immune reconstitution and clinical outcomes of all HSC sources in specific diseases.
AB - Hematopoietic stem cell (HSC) transplantation's success lies in its ability to induce immune reconstitution. To date, there is no review published to compare the immune reconstitution among the three sources of HSC: umbilical cord blood (UCB), bone marrow (BM), and peripheral blood (PB). The review aims to analyze the kinetic of immune reconstitution among UCB, PB, and BM in HSC transplant patients by focusing on natural killer (NK) cells, B and T lymphocytes, and neutrophils. A systematic review was conducted through five databases, searching for clinical trials and randomized control trials (RCTs) which analyze the kinetics of immune reconstitution in at least two sources. Selected studies were assessed with Cochrane RoB 2.0. This review included 14 studies, with a total of 2539 subjects. The PB group achieved the fastest time to neutrophil recovery, while the B-cell count was the highest in the UCB group. The T-cell count is the lowest in the BM group, and the NK-cell count does not differ significantly among the three HSC sources. Among the three sources of HSC, there is no superior HSC source for any immune reconstitution parameter. More studies must be conducted to compare the immune reconstitution and clinical outcomes of all HSC sources in specific diseases.
KW - bone marrow
KW - hematopoietic stem-cell transplantation
KW - immune reconstitution
KW - peripheral blood
KW - umbilical cord blood
UR - http://www.scopus.com/inward/record.url?scp=85152680035&partnerID=8YFLogxK
U2 - 10.1111/ejh.13966
DO - 10.1111/ejh.13966
M3 - Review article
C2 - 36950969
AN - SCOPUS:85152680035
SN - 0902-4441
VL - 111
SP - 4
EP - 14
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 1
ER -