Sand mining activities in the Komering river, South Sumatera, has been existed around a long time and continues to grow along with the increase of development that occurred in the district of East Ogan Komering Ulu (East OKU). The purpose of this study is to examine the impact of sand mining activities to environmental conditions of the Komering river. Field studies have been conducted during the period of April-June 2016 for observing the condition of the river channel, water quality measurement and mining activities. Analysis of the results of field studies combined with GIS and Remote sensing analysis was conducted to measure the impact of mining activities both spatially and temporally. The results showed that the sand mining activities on the Komering river have led not only to the degradation of water quality but also damage of the river channel. In this paper, we also discussed the relationship between the distribution of water quality and channel damage with the mining activities in the spatial perspective.