Impact of diabetes mellitus on COVID-19 clinical symptoms and mortality: Jakarta's COVID-19 epidemiological registry

Dante S. Harbuwono, Dwi O.T.L. Handayani, Endang S. Wahyuningsih, Novita Supraptowati, Ananda, Farid Kurniawan, Syahidatul Wafa, Melly Kristanti, Nico I. Pantoro, Robert Sinto, Heri Kurniawan, Rebekka, Dicky L. Tahapary

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background and aims: While the higher prevalence of diabetes mellitus (DM) at younger age in Indonesia might contribute to the relatively higher COVID-19 mortality rate in Indonesia, there were currently no available evidence nor specific policy in terms of COVID-19 prevention and management among DM patients. We aimed to find out the association between diagnosed diabetes mellitus (DM) with COVID-19 mortality in Indonesia. Methods: We performed a retrospective cohort study using Jakarta Province's COVID-19 epidemiological registry within the first 6 months of the pandemic. All COVID-19 confirmed patients, aged >15 years with known DM status were included. Patients were assessed for their clinical symptoms and mortality outcome based on their DM status. A multivariate Cox-regression test was performed to obtain the relative risk (RR) of COVID-19 mortality in the diagnosed DM group. Results: Of 20,481 patients with COVID-19, 705 (3.4%) had DM. COVID-19 mortality rate in DM group was 21.28%, significantly higher compared to 2.77% mortality in the non-DM group [adjusted RR 1.98 (CI 95% 1.57–2.51), p < 0.001]. In addition, COVID-19 patients with DM generally developed more symptoms. Conclusions: DM is associated not only with development of more COVID-19 clinical symptoms, but also with a higher risk of COVID-19 mortality. This finding may provide a basis for future policy regarding COVID-19 prevention and management among diabetes patients in Indonesia.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalPrimary Care Diabetes
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Clinical symptoms
  • COVID-19
  • Diabetes mellitus
  • Indonesia
  • Mortality

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