Immunomodulatory Activity Based on Total Protein Serum from Indonesian Anti-neurodegenerative Mixed-herb Water Extract

Dewi Tristantini, Nabila Larasati Karlinda, Leon Lukhas Santoso

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Modern lifestyle has made many live in an unhealthy diet and high working stress. Those conditions make a high possibility for anyone to compromise their immune system. In the past, people have used herbal medicine to maintain their health. One of the medicines from Central Java, Indonesia has been used to reduce neural pain and enhanced the immune system for generations. The formula consists of cloves (Syzygium aromaticum), ginger (Zingiber officinale), and nutmeg (Myristica fragrans) with water as the solvent. In this research, the formula's extract was tested for immunomodulatory activity based on total protein serum in mice (Mus musculus). The extraction process used the reflux method with 10 g of dried sample in 250 ml of water at a temperature of 80°C for 90 minutes. The immunomodulatory test was conducted with five mice groups: the normal group, the positive group with immune booster medicine, and three dosage groups derived from 62.5, 125, and 250 mL of mixed-herb extract for 28 days. The result has shown that the formula's extract has high effectiveness in enhancing the total protein amount, which is 28.11% for the lowest dosage and 37.64% for the most significant dosage. Compared to the positive group, the formula's extract tended to increase globulin rather than albumin. Those significant phenomena have also been proven from ANOVA single-factor analysis with 0.05 of confidence level, resulting in a p-value of 0.001. Therefore, the Indonesian Anti-neurodegenerative mixed-herb water extract has been proven to have a high potential as an immunomodulator.

Original languageEnglish
Title of host publication6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021
EditorsSiti Fauziyah Rahman, Ahmad Zakiyuddin, Yudan Whulanza, Nurul Intan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443716
DOIs
Publication statusPublished - 16 Aug 2022
Event6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 - Depok, Virtual, Indonesia
Duration: 7 Jul 20218 Jul 2021

Publication series

NameAIP Conference Proceedings
Volume2537
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Country/TerritoryIndonesia
CityDepok, Virtual
Period7/07/218/07/21

Keywords

  • Albumin
  • Anti-neurodegenerative
  • Globulin
  • Herbal medicine
  • Immunomodulator

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