Immunohistochemical response towards alpha smooth muscle actin post magnesium ECAP miniplate and screw implantation in bone tissue

Fredy Budhi Dharmawan, Sugeng Supriadi, Bambang Pontjo Priosoeryanto, Benny Syariefsyah Latief

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In daily pathology, wound with early and advance complication can result in the increased rate of morbidity and mortality. Wounds resulting from implantation of M agnesium ECAP miniplate and screw to bone tissues are no exception. M agnesium ECAP has been known as a promising biodegradable material in future fracture management. M acroscopically, this process would appear as granulated tissues and angiogenesis which is essential during each phase of reparation process. The walls of newly formed blood vessels can be identified with immunohistochemistry, a modality with high sensitivity and specificity. This study has purpose to evaluate neoangiogenesis created by magnesium ECAP miniplate and screw implantation on microscopic preparations made from rabbits femur with immunohistochemical staining to alpha smooth muscle actin with 1, 3, and 5 months interval. The microscopic preparations are then measured using stain positivity on bone tissue. From this research can be deduced that alpha-smooth muscle actinhas the potential as blood vessel identifier, also the amount and pattern of neoangiogenesis are proportional to time and biodegradation rate.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • alpha smooth muscle actin
  • angiogenesis
  • immunohistochemistry
  • magnesium ECAP

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