In daily pathology, wound with early and advance complication can result in the increased rate of morbidity and mortality. Wounds resulting from implantation of M agnesium ECAP miniplate and screw to bone tissues are no exception. M agnesium ECAP has been known as a promising biodegradable material in future fracture management. M acroscopically, this process would appear as granulated tissues and angiogenesis which is essential during each phase of reparation process. The walls of newly formed blood vessels can be identified with immunohistochemistry, a modality with high sensitivity and specificity. This study has purpose to evaluate neoangiogenesis created by magnesium ECAP miniplate and screw implantation on microscopic preparations made from rabbits femur with immunohistochemical staining to alpha smooth muscle actin with 1, 3, and 5 months interval. The microscopic preparations are then measured using stain positivity on bone tissue. From this research can be deduced that alpha-smooth muscle actinhas the potential as blood vessel identifier, also the amount and pattern of neoangiogenesis are proportional to time and biodegradation rate.