TY - GEN
T1 - Immunohistochemical response towards alpha smooth muscle actin post magnesium ECAP miniplate and screw implantation in bone tissue
AU - Dharmawan, Fredy Budhi
AU - Supriadi, Sugeng
AU - Priosoeryanto, Bambang Pontjo
AU - Latief, Benny Syariefsyah
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/4/9
Y1 - 2019/4/9
N2 - In daily pathology, wound with early and advance complication can result in the increased rate of morbidity and mortality. Wounds resulting from implantation of M agnesium ECAP miniplate and screw to bone tissues are no exception. M agnesium ECAP has been known as a promising biodegradable material in future fracture management. M acroscopically, this process would appear as granulated tissues and angiogenesis which is essential during each phase of reparation process. The walls of newly formed blood vessels can be identified with immunohistochemistry, a modality with high sensitivity and specificity. This study has purpose to evaluate neoangiogenesis created by magnesium ECAP miniplate and screw implantation on microscopic preparations made from rabbits femur with immunohistochemical staining to alpha smooth muscle actin with 1, 3, and 5 months interval. The microscopic preparations are then measured using stain positivity on bone tissue. From this research can be deduced that alpha-smooth muscle actinhas the potential as blood vessel identifier, also the amount and pattern of neoangiogenesis are proportional to time and biodegradation rate.
AB - In daily pathology, wound with early and advance complication can result in the increased rate of morbidity and mortality. Wounds resulting from implantation of M agnesium ECAP miniplate and screw to bone tissues are no exception. M agnesium ECAP has been known as a promising biodegradable material in future fracture management. M acroscopically, this process would appear as granulated tissues and angiogenesis which is essential during each phase of reparation process. The walls of newly formed blood vessels can be identified with immunohistochemistry, a modality with high sensitivity and specificity. This study has purpose to evaluate neoangiogenesis created by magnesium ECAP miniplate and screw implantation on microscopic preparations made from rabbits femur with immunohistochemical staining to alpha smooth muscle actin with 1, 3, and 5 months interval. The microscopic preparations are then measured using stain positivity on bone tissue. From this research can be deduced that alpha-smooth muscle actinhas the potential as blood vessel identifier, also the amount and pattern of neoangiogenesis are proportional to time and biodegradation rate.
KW - alpha smooth muscle actin
KW - angiogenesis
KW - immunohistochemistry
KW - magnesium ECAP
UR - http://www.scopus.com/inward/record.url?scp=85064840966&partnerID=8YFLogxK
U2 - 10.1063/1.5096682
DO - 10.1063/1.5096682
M3 - Conference contribution
AN - SCOPUS:85064840966
T3 - AIP Conference Proceedings
BT - 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Wulan, Praswasti P.D.K.
A2 - Gozan, Misri
A2 - Astutiningsih, Sotya
A2 - Ramahdita, Ghiska
A2 - Dhelika, Radon
A2 - Kreshanti, Prasetyanugraheni
PB - American Institute of Physics Inc.
T2 - 3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Y2 - 6 August 2018 through 8 August 2018
ER -