Immunoglobulin G levels in the gingival crevicular fluid of menopausal patients with periodontitis

Edmond Pradipta Andrianus, Sri Lelyati C. Masulili, Robert Lessang, Fatimah Maria Tadjoedin, Dimas Ilham Hutomo, Pitu Wulandari, Elza Ibrahim Auerkari

Research output: Contribution to journalArticlepeer-review


Objective: To measure the level of immunoglobulin G (IgG) in the gingival crevicular fluid (GCF). Material and Methods: A total of 158 patients aged >45 years were examined for periodontitis and interviewed regarding their menopausal status. The non-menopause group entailed female patients with periodontitis without menopause (n=23). The menopause group included females who stopped menstruating since >1 year, had a pocket depth of 4–5 mm, and did not have other systemic conditions (n=40). Samples were selected based on periodontal and menopausal status. In total, 63 samples of GCF were collected from the participants and tested using an enzyme-linked immunosorbent assay kit for IgG. Results: The median level of IgG in the menopause group was 39.50 mg/mL, whereas that of the non-menopause group was 41.08 mg/mL. There was a positive correlation between the plaque index and IgG level in both groups. In contrast, there was a negative correlation between age and IgG level. However, there was no correlation between plaque index and age regarding the IgG level in both groups (p>0.05). Conclusion: The IgG levels in the menopause group were lower than those in the non-menopause group. As such, menopausal females should take great care of their overall health, including the periodontium.

Original languageEnglish
Article numbere5940
JournalPesquisa Brasileira em Odontopediatria e Clinica Integrada
Publication statusPublished - 2021


  • Immunoglobulin G
  • Menopause
  • Periodontal Diseases
  • Periodontitis


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