Immune responses to filarial parasites

R. M. Maizels, Agnes Kurniawan, M. E. Selkirk, M. Yazdanbakhsh

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Filarial nematode parasites are long-lived organisms which are responsible for one of the major tropical diseases. Their ability to survive may be related to the antigen-specific anergic state observed in carriers of the parasite. Severe disease symptoms are associated with the breakdown of anergy. Different stages of the parasite life cycle are antigenically distinct, and a state of concomitant immunity is therefore possible which prevents superinfection. The evidence for these conclusions is discussed, in the context of the need for an effective vaccine against filarial parasites which will avoid any risk of increasing disease severity.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalImmunology Letters
Volume30
Issue number2
DOIs
Publication statusPublished - 1 Jan 1991

Keywords

  • Anergy
  • Filariasis
  • gp29
  • Immunology
  • Pathology
  • Vaccine

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