TY - JOUR
T1 - Immune checkpoint inhibitor colitis, a rising issue in targeted cancer therapy era
T2 - A literature review
AU - Adiwinata, Randy
AU - Tandarto, Kevin
AU - Tanadi, Caroline
AU - Waleleng, Bradley Jimmy
AU - Haroen, Harlinda
AU - Rotty, Linda
AU - Gosal, Fandy
AU - Rotty, Luciana
AU - Hendratta, Cecilia
AU - Lasut, Pearla
AU - Winarta, Jeanne
AU - Waleleng, Andrew
AU - Simadibrata, Paulus
AU - Simadibrata, Marcellus
N1 - Publisher Copyright:
© 2024 Randy Adiwinata et al., published by Sciendo.
PY - 2024/9/1
Y1 - 2024/9/1
N2 - Research advances in the oncology treatment field have led to the widespread use of immunotherapy. The usage of immune checkpoint inhibitor (ICI) has improved the survival of cancer patients with metastases. This has also led to the rapidly expanding indications for ICI use. However, ICI usage may lead to toxicity, which may be immune-related, in different organ-specific targets. The immune-related adverse events (irAEs) of ICI may lead to increased morbidity, decreased quality of life, and early termination of ICI. The clinical manifestations of irAEs in the gastrointestinal system are variable, ranging from self-limited to life-threatening or fatal events. In this review article, we would like to focus on discussing ICI-induced colitis, which is one of the most common ICI irAEs in the gastrointestinal tract.
AB - Research advances in the oncology treatment field have led to the widespread use of immunotherapy. The usage of immune checkpoint inhibitor (ICI) has improved the survival of cancer patients with metastases. This has also led to the rapidly expanding indications for ICI use. However, ICI usage may lead to toxicity, which may be immune-related, in different organ-specific targets. The immune-related adverse events (irAEs) of ICI may lead to increased morbidity, decreased quality of life, and early termination of ICI. The clinical manifestations of irAEs in the gastrointestinal system are variable, ranging from self-limited to life-threatening or fatal events. In this review article, we would like to focus on discussing ICI-induced colitis, which is one of the most common ICI irAEs in the gastrointestinal tract.
KW - Colitis
KW - Enterocolitis
KW - Immune checkpoint inhibitors
KW - Immunotherapy
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=85202790460&partnerID=8YFLogxK
U2 - 10.2478/rjim-2024-0015
DO - 10.2478/rjim-2024-0015
M3 - Review article
C2 - 38595047
AN - SCOPUS:85202790460
SN - 1220-4749
VL - 62
SP - 219
EP - 230
JO - Romanian journal of internal medicine = Revue roumaine de medecine interne
JF - Romanian journal of internal medicine = Revue roumaine de medecine interne
IS - 3
ER -
