TY - JOUR
T1 - IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis
AU - Rahmawati, Nanda Yuli
AU - Ahsan, Fadhil
AU - Santoso, Budi
AU - Mufid, Alfin Firasy
AU - Sa’adi, Ashon
AU - Dwiningsih, Sri Ratna
AU - Tunjungseto, Arif
AU - Widyanugraha, Muhammad Yohanes Ardianta
N1 - Publisher Copyright:
VC The Author(s) 2023. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Objective: To evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain. Methods: Eighty-seven women were diagnosed with endometriosis or cases related to infertility. IL-1b, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid were determined by enzyme-linked immunosorbent assay (ELISA). Pain assessment was evaluated by the Visual Analog Scale (VAS) score. Results: Serum IL-6 and IL-12p70 levels increased in women with endometriosis compared to the control group. Serum and peritoneal IL-8 and IL-12p70 levels correlated with VAS scores in infertile women. A positive correlation was also found between peritoneal IL-1b and IL-6 with VAS score. A significant difference in peritoneal IL-1b levels was associated with menstrual pelvic pain, while peritoneal IL-8 levels were related to dyspareunia, menstrual, and post-menstrual pelvic pain in infertile women. Conclusions: An association of IL-8 and IL-12p70 levels were related to pain in endometriosis, as well as a relationship between cytokine expression and VAS score. Further studies should be addressed to investigate the precise mechanism of cytokine-related pain in endometriosis.
AB - Objective: To evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain. Methods: Eighty-seven women were diagnosed with endometriosis or cases related to infertility. IL-1b, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid were determined by enzyme-linked immunosorbent assay (ELISA). Pain assessment was evaluated by the Visual Analog Scale (VAS) score. Results: Serum IL-6 and IL-12p70 levels increased in women with endometriosis compared to the control group. Serum and peritoneal IL-8 and IL-12p70 levels correlated with VAS scores in infertile women. A positive correlation was also found between peritoneal IL-1b and IL-6 with VAS score. A significant difference in peritoneal IL-1b levels was associated with menstrual pelvic pain, while peritoneal IL-8 levels were related to dyspareunia, menstrual, and post-menstrual pelvic pain in infertile women. Conclusions: An association of IL-8 and IL-12p70 levels were related to pain in endometriosis, as well as a relationship between cytokine expression and VAS score. Further studies should be addressed to investigate the precise mechanism of cytokine-related pain in endometriosis.
KW - cytokines
KW - endometriosis
KW - infertility
KW - pelvic pain
UR - http://www.scopus.com/inward/record.url?scp=85176494879&partnerID=8YFLogxK
U2 - 10.1093/pm/pnad080
DO - 10.1093/pm/pnad080
M3 - Article
C2 - 37326977
AN - SCOPUS:85176494879
SN - 1526-2375
VL - 24
SP - 1262
EP - 1269
JO - Pain Medicine (United States)
JF - Pain Medicine (United States)
IS - 11
ER -