IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis

Nanda Yuli Rahmawati, Fadhil Ahsan, Budi Santoso, Alfin Firasy Mufid, Ashon Sa’adi, Sri Ratna Dwiningsih, Arif Tunjungseto, Muhammad Yohanes Ardianta Widyanugraha

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: To evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid in women related to infertility and pelvic pain. Methods: Eighty-seven women were diagnosed with endometriosis or cases related to infertility. IL-1b, IL-6, IL-8, and IL-12p70 levels in serum and peritoneal fluid were determined by enzyme-linked immunosorbent assay (ELISA). Pain assessment was evaluated by the Visual Analog Scale (VAS) score. Results: Serum IL-6 and IL-12p70 levels increased in women with endometriosis compared to the control group. Serum and peritoneal IL-8 and IL-12p70 levels correlated with VAS scores in infertile women. A positive correlation was also found between peritoneal IL-1b and IL-6 with VAS score. A significant difference in peritoneal IL-1b levels was associated with menstrual pelvic pain, while peritoneal IL-8 levels were related to dyspareunia, menstrual, and post-menstrual pelvic pain in infertile women. Conclusions: An association of IL-8 and IL-12p70 levels were related to pain in endometriosis, as well as a relationship between cytokine expression and VAS score. Further studies should be addressed to investigate the precise mechanism of cytokine-related pain in endometriosis.

Original languageEnglish
Pages (from-to)1262-1269
Number of pages8
JournalPain Medicine (United States)
Volume24
Issue number11
DOIs
Publication statusPublished - 1 Nov 2023

Keywords

  • cytokines
  • endometriosis
  • infertility
  • pelvic pain

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