Securing the confidency of health information in health care industry has been a notable matter. Nursing students are still inexperienced and are in progress to thriving their individual worths and trusts on the significance of Health Information Security Awareness (HISA) and Patient' Health Information Protection Awareness (PHIPA). The objectives of this study is to identify the influence of HISA in PHIPA, to measure the quality of HISA and PHIPA of nursing students in Baturaja and to provide recommendations on HISA and PHIPA improvement on nursing education. Thirty-two questions have been designed in the questionnaire and 94 respondents valid data were continued to analysed using Partial Least Squares (PLS). Based on the analysis results, HISA influences nursing students' communication, management and referral factors in PHIPA in positive ways. And the measurement results shown that nursing students in Baturaja has a well quality of HISA and PHIPA. Our discovery in this study also supply implications for practice the nursing schools and the health care industry about planning extended curriculum and clinical practice guiding principle to simplify students' health information security awareness and patient' health information protection awareness.