Micro, small, and medium enterprises (MSMEs) in Indonesia are an important factor in the Indonesian economy. The total of MSMEs in Indonesia reaches 64.2 million and MSMEs contribute 60.6% of Indonesia's gross domestic product (GDP). Increasing product competitiveness can be done through the implementation of standards, the fact that MSME products have been standardized on products is that the products are certified (Indonesian National Standard). Total MSMEs that have obtained product certification in Indonesia are only 101 MSMEs out of the total number of MSMEs in Indonesia which reaches 64.2 million. Hence, research is needed identification interest in certification of MSME products in Indonesia according to the challenges and benefits of product certification. To obtain data, this paper undertakes a systemic review of the literature covering the challenges and benefits of product certification on MSMEs in Indonesia to identify how challenges and benefits in the MSMEs, correlates with MSMEs survival improvement in the global competition. The results of the analysis of the obtained factors can be used as a basis for the right strategy to increase the product certification on MSMEs in Indonesia.