Identification by docking simulation and in vivo effect of essential oil from Cinnamommum burmannii as anti-obesity with leptin receptor in the olfactory system of mice Balb C

Kusmardi, Aryo Tedjo, Fadilah, Ade Arsianti, Rafika Indah Paramita

Research output: Contribution to journalArticle

Abstract

Aim: This study examines the effect of inhalation of essential oil of cinnamon (Cinnamomum burmannii) on the metabolic activity of hormone receptors olfactory system of mice Balb C. Methodology: Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. Result: The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from Cinnamommum burmannii and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.

Original languageEnglish
Pages (from-to)875-879
Number of pages5
JournalPharmacognosy Journal
Volume10
Issue number5
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Cinnamomum burmannii
  • Docking simulation
  • Immunohistochemistry
  • Leptin receptors
  • Olfactory system

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