TY - JOUR
T1 - Hypercholesterolemia as the first manifestation of metabolic abnormalities in normoglycemic young adult male with family history of type 2 diabetes mellitus
AU - Purnamasari, Dyah
AU - Aulia, Rezky
AU - Abdaly, Muhammad Syah
AU - Hazim, Ahmad
N1 - Funding Information:
We would like to thank all subject who participated in this study. This work was supported by Hibah PITTA 2018 funded by Research and Society Services Directorate , Universitas Indonesia for supporting the finance of this research. We also thank to Cluster Metabolic and Vascular Aging, Indonesian Medical Education and Research Institute (IMERI) team for their support in collecting blood sample and examination.
Publisher Copyright:
© 2019 Diabetes India
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background: Although several studies reported high number of metabolic disorder among First Degree Relatives (FDR) of Type 2 Diabetes Mellitus (T2DM), only a few studies analyzed the impact of gender on the occurence of metabolic abnormalities. Aims: This study aimed to investigate the first manifestation of metabolic abnormalities in normoglycemic FDR of T2DM. Methods and materials: This cross-sectional study recruited 60 FDR of T2DM age of 19–39 years old in Jakarta, Indonesia. We matched 60 non-FDR as controls. All participants had neither glucose intolerance nor hypertension. Anthropometry, body composition and laboratory measurements (blood glucose, HbA1c, lipid profile, liver and kidney function test) were assessed. Results: In males, FDR aged 30–39 years old had higher Total Cholesterol (TC) level ([233 ± 51.43 mg/dL vs. 177.83 ± 22.08 mg/dL, p = 0.036] and Low Density Lipoprotein Cholesterol (LDL-C) level [173.83 ± 39.83 mg/dL vs. 125.67 ± 21.50 mg/dL, p = 0.026] than those of non-FDR significantly. FDR also had higher risk of hypercholesterolemia than non-FDR [OR 5.25 (1.09–25.21)]. There were no differences of metabolic abnormalities between female FDR and non-FDR group. Conclusion: Male FDR of T2DM showed higher level of TC and LDL-C level than those of non FDR. Male FDR also showed higher risk of dyslipidemia.
AB - Background: Although several studies reported high number of metabolic disorder among First Degree Relatives (FDR) of Type 2 Diabetes Mellitus (T2DM), only a few studies analyzed the impact of gender on the occurence of metabolic abnormalities. Aims: This study aimed to investigate the first manifestation of metabolic abnormalities in normoglycemic FDR of T2DM. Methods and materials: This cross-sectional study recruited 60 FDR of T2DM age of 19–39 years old in Jakarta, Indonesia. We matched 60 non-FDR as controls. All participants had neither glucose intolerance nor hypertension. Anthropometry, body composition and laboratory measurements (blood glucose, HbA1c, lipid profile, liver and kidney function test) were assessed. Results: In males, FDR aged 30–39 years old had higher Total Cholesterol (TC) level ([233 ± 51.43 mg/dL vs. 177.83 ± 22.08 mg/dL, p = 0.036] and Low Density Lipoprotein Cholesterol (LDL-C) level [173.83 ± 39.83 mg/dL vs. 125.67 ± 21.50 mg/dL, p = 0.026] than those of non-FDR significantly. FDR also had higher risk of hypercholesterolemia than non-FDR [OR 5.25 (1.09–25.21)]. There were no differences of metabolic abnormalities between female FDR and non-FDR group. Conclusion: Male FDR of T2DM showed higher level of TC and LDL-C level than those of non FDR. Male FDR also showed higher risk of dyslipidemia.
KW - First degree relatives (FDR)
KW - Gender
KW - Metabolic abnormalities
KW - Type 2 diabetes mellitus (T2DM)
UR - http://www.scopus.com/inward/record.url?scp=85059652326&partnerID=8YFLogxK
U2 - 10.1016/j.dsx.2018.12.019
DO - 10.1016/j.dsx.2018.12.019
M3 - Article
AN - SCOPUS:85059652326
SN - 1871-4021
VL - 13
SP - 969
EP - 974
JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews
JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews
IS - 2
ER -