Hypercholesterolemia as the first manifestation of metabolic abnormalities in normoglycemic young adult male with family history of type 2 diabetes mellitus

Rr. Dyah Purnamasari Sulistianingsih, Rezky Aulia, Muhammad Syah Abdaly, Ahmad Hazim

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although several studies reported high number of metabolic disorder among First Degree Relatives (FDR) of Type 2 Diabetes Mellitus (T2DM), only a few studies analyzed the impact of gender on the occurence of metabolic abnormalities. Aims: This study aimed to investigate the first manifestation of metabolic abnormalities in normoglycemic FDR of T2DM. Methods and materials: This cross-sectional study recruited 60 FDR of T2DM age of 19–39 years old in Jakarta, Indonesia. We matched 60 non-FDR as controls. All participants had neither glucose intolerance nor hypertension. Anthropometry, body composition and laboratory measurements (blood glucose, HbA1c, lipid profile, liver and kidney function test) were assessed. Results: In males, FDR aged 30–39 years old had higher Total Cholesterol (TC) level ([233 ± 51.43 mg/dL vs. 177.83 ± 22.08 mg/dL, p = 0.036] and Low Density Lipoprotein Cholesterol (LDL-C) level [173.83 ± 39.83 mg/dL vs. 125.67 ± 21.50 mg/dL, p = 0.026] than those of non-FDR significantly. FDR also had higher risk of hypercholesterolemia than non-FDR [OR 5.25 (1.09–25.21)]. There were no differences of metabolic abnormalities between female FDR and non-FDR group. Conclusion: Male FDR of T2DM showed higher level of TC and LDL-C level than those of non FDR. Male FDR also showed higher risk of dyslipidemia.

Original languageEnglish
Pages (from-to)969-974
Number of pages6
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • First degree relatives (FDR)
  • Gender
  • Metabolic abnormalities
  • Type 2 diabetes mellitus (T2DM)

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