Indonesia has taken an active role in the phase-out of ozone depleting substances and reduction of high global warming potential substances in refrigeration systems. For RAC applications, the choice has been geared toward the use of natural refrigerant with hydrocarbons shows a great potential. This paper presents review on the development of hydrocarbon refrigerant applications in Indonesia. As a case study, the installation, performance measurement and safety analysis of a hydrocarbon (R290) refrigerant for ice slurry equipment and chiller in an auditorium building at Universitas Indonesia are presented. Field measurement was performed on refrigerant, cooling water and air sides to obtain its performance. The paper also presents analysis on the flammability aspects, charge limit and applicable national standards for its safe use and handling and benchmarking with international standard. The study showed that the hydrocarbon chiller is an energy efficient and safe option for refrigeration application in Indonesia.