Hyaluronic Acid and Chlorine Dioxide on Post-odontectomy Swelling and Pain: A Randomised Controlled Trial

Yudy Ardilla Utomo, Jihan Fasya Alifia, Lilies Dwi Sulistyani, Vera Julia, Dwi Ariawan, Muhammad Ramaditto Reksoprodjo

Research output: Contribution to journalArticlepeer-review


Gels containing hyaluronic acid (HA) and chlorine dioxide (ClO2) can be used to treat postodontectomy swelling and pain. There is minimal study comparing the outcome of these preparations. This study aims to compare swelling and pain in post-odontectomy patients treated with HA and ClO2 gels. Material and methods: A RCT with three parallel arms were designed for this study. 165 patients with impacted third molar were included and allocated into HA-treated, ClO2-treated, and control group (n=55). The measurement is using Gabka and Matsumara technique and numeric rating scale. Data was collected during the same day, 2-days, and 7-days after surgery. Median pain scores on HA, ClO2 were lower than the control group on the same day (HA=6, ClO2=7, control=8; p<0.001) and on the second collection (HA=1, ClO2=2, control=3; p<0.001) and in the third collection were 0 in all groups (p<0.001). The median value of swelling was measured at 14.6 cm in all groups before surgery. On the second and third measurement, the median value of swelling on HA and ClO2 groups were minimally reduced compared to the control group (p>0.05). HA and ClO2 treatment reduces post-odontectomy pain score, and minimal effects on swelling were observed.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number2
Publication statusPublished - 2023


  • Chlorine dioxide
  • hyaluronic acid
  • odontectomy
  • oral surgery
  • third-molar


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