Hpv 52 most dominant human papillomavirus (Hpv) genotype in women infected by human immunodeficiency virus (hiv) that get antiretroviral treatment (art)

Risnawati, Ariawan Soejoenoes, Suharyo Hadisaputro, Muchlis Au Sofro, Samsuridjal Djauzi, Noor Pramono, Ari Suwondo, Dendi Durahman, Julian Pratama

Research output: Contribution to journalArticlepeer-review

Abstract

Background:: the persistence of oncogenic or high-risk HPV infection (HPV-RT) is a causative agent of cervical cancer, a cancer with the highest prevalence in Indonesia. HIV-infected women have a higher prevalence of RT-HPV infection than HIV-uninfected women. The aim of the study was to assess the distribution of HPV genotypes in HIV-infected women who received ART. Methods:: Analytical, cross-sectional study of 55 HIV-infected women between December 2019-March 2020 aged 24-51 years at the Dr. Kariadi Semarang and Salatiga City Hospital. HPV genotype examination method used Reserve Dot Blot "Flow-Trough" Hybridization method Results:: HPV DNA was detected 53%. Four samples (5.1%) could not be further categorized. 50% of respondents detected the HPV-RT genotype. The most common HPV-RT genotypes were HPV52 (7.7%), HPV68 (6.3%), and HPV66 (5.1%), whereas for low risk HPV genotypes (HPV-RR) which frequently appeared were HPV43 (6.3%), HPV44 (6.3%), and HPV6 (5.1%). Conclusions:: the results of this study indicate the diversity of HPV genotypes in HIV-infected women and the most dominant genotype is HPV52.

Original languageEnglish
Pages (from-to)2568-2573
Number of pages6
JournalInternational Journal of Pharmaceutical Research
Volume12
Issue number4
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • Genotype
  • High risk HPV
  • HIV infected women
  • Low risk HPV

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