This study aims to analyze the level of information literacy in housewives in addressing hoax information in the field of health in social media. Information on health is abundantly appearing on the internet, although not all of them are true and worth following. It requires housewives to have an information literacy capability, a capability that allows the individual to be aware of when he needs information, locates, evaluates, and uses the required information effectively. This research was conducted in Depok City, West Java, Indonesia, as city buffer of capital city. This research uses quantitative approach and using survey method. The sample of this research is selected using purposive sampling method. The research question is how the information literacy on housewives in addressing health hoax information in social media, as well as the difficulties and obstacles they face in collecting, processing up to address the hoax information in social media. The research benefits are aimed at the academic and social field. In the academic field, the results of this study are expected to encourage the development of library and information science in the aspect of information literacy, especially in the field of health. In the social field, the results of this study are expected to help government agencies, especially those engaged in health in disseminating information to housewives by providing information to housewives through sources and facilities and language that is easy to understand. Furthermore, similar institutions are expected to improve the quality of information disseminated and can meet the needs of public information.