HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia

Herlyani Khosama; Astri Budikayanti; Amy Hui Ping Khor; Kheng Seang Lim; Ching Ching Ng; Indra G. Mansyur; Alida Harahap; Teguh A.R. Ranakusuma; Chong Tin Tan

HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia

Herlyani Khosama, Astri Budikayanti, Amy Hui Ping Khor, Kheng Seang Lim, Ching Ching Ng, Indra G. Mansyur, Alida Harahap, Teguh A.R. Ranakusuma, Chong Tin Tan

Department of Neurology

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background & Objective: Association between HLA-B*1502 and carbamazepine-induced Steven-Johnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035). Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Neurology Asia
Volume	22
Issue number	2
Publication status	Published - 2017

Keywords

Carbamazepine induced Steven-Johnson syndrome/toxic epidermal necrolysis
HLA-B*1502
Hypersensitivity
Indonesia

Cite this

@article{b5e827932f604f848acdec28ffbc45e5,

title = "HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia",

abstract = "Background & Objective: Association between HLA-B*1502 and carbamazepine-induced Steven-Johnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035). Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.",

keywords = "Carbamazepine induced Steven-Johnson syndrome/toxic epidermal necrolysis, HLA-B*1502, Hypersensitivity, Indonesia",

author = "Herlyani Khosama and Astri Budikayanti and Khor, {Amy Hui Ping} and Lim, {Kheng Seang} and Ng, {Ching Ching} and Mansyur, {Indra G.} and Alida Harahap and Ranakusuma, {Teguh A.R.} and Tan, {Chong Tin}",

year = "2017",

language = "English",

volume = "22",

pages = "113--116",

journal = "Neurology Asia",

issn = "1823-6138",

publisher = "ASEAN Neurological Association",

number = "2",

}

TY - JOUR

T1 - HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia

AU - Khosama, Herlyani

AU - Budikayanti, Astri

AU - Khor, Amy Hui Ping

AU - Lim, Kheng Seang

AU - Ng, Ching Ching

AU - Mansyur, Indra G.

AU - Harahap, Alida

AU - Ranakusuma, Teguh A.R.

AU - Tan, Chong Tin

PY - 2017

Y1 - 2017

N2 - Background & Objective: Association between HLA-B*1502 and carbamazepine-induced Steven-Johnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035). Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.

AB - Background & Objective: Association between HLA-B*1502 and carbamazepine-induced Steven-Johnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035). Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.

KW - Carbamazepine induced Steven-Johnson syndrome/toxic epidermal necrolysis

KW - HLA-B1502

KW - Hypersensitivity

KW - Indonesia

UR - http://www.scopus.com/inward/record.url?scp=85021791736&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85021791736

SN - 1823-6138

VL - 22

SP - 113

EP - 116

JO - Neurology Asia

JF - Neurology Asia

IS - 2

ER -

HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia

Abstract

Keywords

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