HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia

Herlyani Khosama, Astri Budikayanti, Amy Hui Ping Khor, Kheng Seang Lim, Ching Ching Ng, Indra G. Mansyur, Alida Harahap, Teguh A.R. Ranakusuma, Chong Tin Tan

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background & Objective: Association between HLA-B*1502 and carbamazepine-induced Steven-Johnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035). Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalNeurology Asia
Volume22
Issue number2
Publication statusPublished - 1 Jan 2017

Keywords

  • Carbamazepine induced Steven-Johnson syndrome/toxic epidermal necrolysis
  • HLA-B*1502
  • Hypersensitivity
  • Indonesia

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