Histopathological study on basal cell carcinoma and squamous cell carcinoma of the skin

Mpu Kanoko, Achmad Tjarta, Masato Ueda, Mochtar Hamzah, Herman Cipto, Evert Poetiray, Arman Mukhtar, Santoso Cornain, Joedo Prihartono, Setyawati Budiningsih, Yoshiyuki Ohno, Nobuo Munakata, Masamitsu Ichihashi

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1 Citation (Scopus)

Abstract

A collaborative study on skin cancer has been conducted to analyze the risk factors and clinico-pathological characteristics of skin cancers among both the Indonesian and the Japanese. In this study. we have analyzed the histopathologicxd features of non-melanoma skin cancer (NMSC). basal cell carrinoma (BCC) and squamous cell carcinoma (SCCJ of Indonesian patients. Considering the fact that ultraviolet light (UV) radiation is the major cause of NMSC. we focus on studying the relationship between the histopathological finding and the location of the tumors, whether they were developed on sun-exposed sites or sun-protected sites. In addition, becausc it has been revealed that the size of NMSC in Indonesian was larger than those in Japanese, we also attempted to find the relationship between the tumor size of NMSC and the pathological characteristics. From period of 1996 to 1998, we could analyze the histopathological features in 40 cases of BCC and 16 cases of SCC. Among BCC. the pathobgical typing according to the differentiation revealed that 28 cases were solid. 5 cases were adenoid. 2 cases were kcratotic and the remaining 5 cases were mixed type (solid-adenoid or kcratotic- adenoid). Among SCC 16 cases were classified as well- differentiated type in 12 cases and moderate-differentiated type in 4 cases. Since 39 of 40 cases of BCC developed on sun-exposed sites, the comparison of pathological findings in relation to the effect of UV-exposure was not possible. Of 16 SCC, 9 cases were from sun-exposed sites (face and arm) and 7 cases were from sun-protected sites. No clear difference of pathological findings between SCC on sun- exposed sites and SCC on sun-protected hot found. Of 40 cases of BCC 9 cases were I cm or less in diameter (small BCC) and 31 cases were more than 1 cm (large BCC). Large BCC included 13 cases sclerosing infiltrative type It seems that large sized BCC were frequently associated with sclerosing infiltrative type pathologically. The effect of UVon [radiological changes in NMSC will be further examined using a higher number of cases. Of 16 cases of SCC, 7 cases were 1 cm or less in diameter (small SCC) and 9 cases were more than 1 cm (large SCC). There was no difference in differentiation of the cells between small SCC and large SCC.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalMedical Journal of Indonesia
Volume9
Issue number2
DOIs
Publication statusPublished - 1 Apr 2000

Keywords

  • Basal cell carcinoma
  • Histopathological type
  • Skin cancer
  • Squamous cell carcinoma

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