Histopathological aspects of breast cancer in relation to some epidemiological risk factors

Esti Soetrisno, Gunawan Tjahjadi, Goi Sakamoto, Joedo Prihartono, Yoshiyuki Ohno, Didid Tjindarbumi, Santoso Cornain, Setyawati Budiningsih, Sadao Suzuki, Muchlis Ramli, Idral Darwis, Endang Sri Roostini Hardianto, Kenji Wakai, Drupadi Harnopidjati

Research output: Contribution to journalArticlepeer-review


Case control epidemiological study of 300 breast cancer cases from Dr. Cipto Mangunkusumo Hospital has been performed in 1989-1991. By applying the Japanese Breast Cancer Society classification, the histopathological pattern of breast cancer showed that from the invasive ductal carcinoma type, scirrhous type was found in 147 cases (49%), solid-tubular type in 79 cases (26.33%) and papilotubular type in 39 cases (13%). According to WHO classification (1981); they were diagnosed as: invasive ductal carcinoma in 265 cases (88.33%), invasive lobular carcinoma in 7 cases (2.33%), medullary carcinoma in 17 cases (5.68%), adenoid cystic carcinoma in 1 case (0.33%), pure Pagets disease of the nipple in 2 cases (0.67%) and 4 cases (1.33%) of the noninvasive carcinoma were ductal carcinoma in situ. Analysis of the significant risk factors among the Indonesian female breast cancer revealed that the following factors: living at urban area, young sexual activity, trauma, obesity, late menarche, irregular cycle, menopause, fatty diet and coconut milk con­taining food consumption increased the risk. Relationship of the risk factors to histopathological types has been stastistically analyzed. The results showed that increased possibility to have the invasive ductal carcinoma was related to consumption of coconut milk containing food. The effect was related to the three histological subtypes, namely: papillary tubular, solid tubular and scirrhous types. Coconut milk drinks and fresh vegetables showed decreasing effect, which was irrespective to subtypes.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalMedical Journal of Indonesia
Issue number2
Publication statusPublished - 1 Apr 1999


  • Breast cancer
  • Epidemiological
  • Histopathological
  • Risk factors


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