Histopathological and biomarker complete response after neoadjuvant chemotherapy of advanced stage yolk sac tumor of the ovary: A case report and literature review

Tofan Widya Utami, Yuri Feharsal, Laila Nuranna, Gatot Purwoto, Trifonia Pingkan Siregar, Tantri Hellyanti

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Yolk sac tumor is the second most common germ cell ovarian carcinoma. Neoadjuvant chemotherapy (NACT) is proposed as an alternative option for patients with advanced disease who are not eligible for primary debulking. We presented a case with a systematic review of advanced yolk sac tumors of the ovary with poor performance who gain benefit from NACT. Case presentation: A 24-year-old female underwent NACT followed by surgery after being diagnosed with an advanced yolk sac tumor. A literature search was done based on the clinical question using the Patient/Problem, Intervention, Comparison, and Outcome (PICO) approach. Pubmed and Google Scholar were used to search the literature. Discussion: Out of 111 manuscripts found, 2 articles were retrieved for detailed evaluation. The patient showed a complete response in tumor size, histopathology, and tumor markers after the NACT procedure followed by surgery. Conclusions: NACT is a suitable option for advanced yolk sac tumors of the ovary.

Original languageEnglish
Article number108915
JournalInternational Journal of Surgery Case Reports
Volume112
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Alpha-fetoprotein
  • Evidence-based case report
  • Neoadjuvant chemotherapy
  • Yolk sac tumor

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