TY - JOUR
T1 - Histopathological and biomarker complete response after neoadjuvant chemotherapy of advanced stage yolk sac tumor of the ovary
T2 - A case report and literature review
AU - Utami, Tofan Widya
AU - Feharsal, Yuri
AU - Nuranna, Laila
AU - Purwoto, Gatot
AU - Siregar, Trifonia Pingkan
AU - Hellyanti, Tantri
N1 - Publisher Copyright:
© 2023
PY - 2023/11
Y1 - 2023/11
N2 - Introduction: Yolk sac tumor is the second most common germ cell ovarian carcinoma. Neoadjuvant chemotherapy (NACT) is proposed as an alternative option for patients with advanced disease who are not eligible for primary debulking. We presented a case with a systematic review of advanced yolk sac tumors of the ovary with poor performance who gain benefit from NACT. Case presentation: A 24-year-old female underwent NACT followed by surgery after being diagnosed with an advanced yolk sac tumor. A literature search was done based on the clinical question using the Patient/Problem, Intervention, Comparison, and Outcome (PICO) approach. Pubmed and Google Scholar were used to search the literature. Discussion: Out of 111 manuscripts found, 2 articles were retrieved for detailed evaluation. The patient showed a complete response in tumor size, histopathology, and tumor markers after the NACT procedure followed by surgery. Conclusions: NACT is a suitable option for advanced yolk sac tumors of the ovary.
AB - Introduction: Yolk sac tumor is the second most common germ cell ovarian carcinoma. Neoadjuvant chemotherapy (NACT) is proposed as an alternative option for patients with advanced disease who are not eligible for primary debulking. We presented a case with a systematic review of advanced yolk sac tumors of the ovary with poor performance who gain benefit from NACT. Case presentation: A 24-year-old female underwent NACT followed by surgery after being diagnosed with an advanced yolk sac tumor. A literature search was done based on the clinical question using the Patient/Problem, Intervention, Comparison, and Outcome (PICO) approach. Pubmed and Google Scholar were used to search the literature. Discussion: Out of 111 manuscripts found, 2 articles were retrieved for detailed evaluation. The patient showed a complete response in tumor size, histopathology, and tumor markers after the NACT procedure followed by surgery. Conclusions: NACT is a suitable option for advanced yolk sac tumors of the ovary.
KW - Alpha-fetoprotein
KW - Evidence-based case report
KW - Neoadjuvant chemotherapy
KW - Yolk sac tumor
UR - http://www.scopus.com/inward/record.url?scp=85174488093&partnerID=8YFLogxK
U2 - 10.1016/j.ijscr.2023.108915
DO - 10.1016/j.ijscr.2023.108915
M3 - Article
AN - SCOPUS:85174488093
SN - 2210-2612
VL - 112
JO - International Journal of Surgery Case Reports
JF - International Journal of Surgery Case Reports
M1 - 108915
ER -