TY - JOUR
T1 - High mobility group at-hook 2 expression is elevated in cervical cancer
AU - Hartanti, Monica Dwi
AU - Rachmadhany, Elsha Dwi Anggun
AU - Mustopa, Ita Tazkiatul Izzati
AU - Syaputra, Elrian
AU - Sutanto, Elfira
AU - Purwoto, Gatot
N1 - Funding Information:
The authors would like to thank Trisakti University for its support towards the completion of this research under the Trisakti University Research Grant, Trisakti Biomolecular Laboratory for providing access to analyze our samples, Dr. Cipto Mangunkusumo National Public Hospital and Trisakti Health Centre for providing a place for sample collection.
Publisher Copyright:
© 2020, Advanced Scientific Research. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Cervical cancer is the fourth most common type of cancer in women after breast, colorectal, and lung cancers. Cervical cancer is a disease caused by the Human Papilloma Virus (HPV). A previous study found “hot spots” in the human genome that is predicted to be integration points of HPV containing several genes, such as highmobility group AT-hook 2 (HMGA2), semaphorins Class3 Subgroup D (SEMA3D), and kruppel-like factor 12 (KLF12). Various studies have shown that these genes play a critical role in cell proliferation, apoptosis, migration, which are important factors in the development of cancer. This study explores the DNA expression of the HMGA2, SEMA3D, and KLF12 genes in cervical cancer. Using qPCR, this cross-sectional study analyzed those gene expressions quantitatively in normal and cervical cancer groups. An independent t-test was used to analyze the data and p<0.05 was considered significant. There was a significantly higher expression level of HMGA2 in the cervical cancer group compared to the normal group. Other genes were expressed lower in the cervical cancer group compared to normal although it was not statistically significant. HMGA2 might have an important role in the development of cervical cancer.
AB - Cervical cancer is the fourth most common type of cancer in women after breast, colorectal, and lung cancers. Cervical cancer is a disease caused by the Human Papilloma Virus (HPV). A previous study found “hot spots” in the human genome that is predicted to be integration points of HPV containing several genes, such as highmobility group AT-hook 2 (HMGA2), semaphorins Class3 Subgroup D (SEMA3D), and kruppel-like factor 12 (KLF12). Various studies have shown that these genes play a critical role in cell proliferation, apoptosis, migration, which are important factors in the development of cancer. This study explores the DNA expression of the HMGA2, SEMA3D, and KLF12 genes in cervical cancer. Using qPCR, this cross-sectional study analyzed those gene expressions quantitatively in normal and cervical cancer groups. An independent t-test was used to analyze the data and p<0.05 was considered significant. There was a significantly higher expression level of HMGA2 in the cervical cancer group compared to the normal group. Other genes were expressed lower in the cervical cancer group compared to normal although it was not statistically significant. HMGA2 might have an important role in the development of cervical cancer.
KW - Cervical cancer
KW - DNA
KW - Gene expression
KW - HPV
UR - http://www.scopus.com/inward/record.url?scp=85090202618&partnerID=8YFLogxK
U2 - 10.31838/ijpr/2020.12.04.322
DO - 10.31838/ijpr/2020.12.04.322
M3 - Article
AN - SCOPUS:85090202618
VL - 12
SP - 2332
EP - 2338
JO - Journal of International Pharmaceutical Research
JF - Journal of International Pharmaceutical Research
SN - 0975-2366
IS - 4
ER -
