High Intermittent Intensity Training Induces FGF21 Secretion in Obese Rats

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Abstract

The browning of adipose tissue is used as one of possible ways to manage obesity. Physical exercise induces the secretion of myokin fibroblast growth factor 21 (FGF21) as a browning mediator in the adipose tissue. This study aims to determine the effect of high intermittent intensity training (HIIT) induced and continuous moderate intensity training (CMIT) induced FGF21 secretion in skeletal muscle, serum, and adipose tissue. This study involved 18 to 20 week old male Sprague Dawley rats that were divided into four groups: (1) a normal group with the standard diet and HIIT (F1-N); (2) a normal group with the standard diet and CMIT (F2-N); (3) an obese group with high fat diet and HIIT (F1-O); and (4) an obese group with high fat diet and CMIT (F2-O). Our results showed that the HIIT group had higher FGF21 levels than the CMIT group in skeletal muscle and adipose tissue. However, there was no difference between the HIIT group and the CMIT group in serum. Physical exercise with HIIT resulted in a higher level of FGF21 as a browning mediator for obesity treatment.
Original languageEnglish
Pages (from-to)1-3
JournalJournal of Obesity and Metabolism
Volume1
Issue number1
Publication statusPublished - 6 Aug 2018

Keywords

  • Obesity
  • Exercise
  • High intermitten intensity training
  • FGF21

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