Hepatoprotector effects of press needle acupuncture of GB34 and BL18 against isoniazid and rifampicin induced liver injury in Wistar rats

A. M. Jufriansjah, C. Simadibrata, A. Srilestari, E. H. Purwaningsih, M. Stephanie

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Treatment for tuberculosis typically consists of a combination of 5 drugs, of which isonicotinylhydrazide (INH) and rifampicin are the most significant ones. However, they are also associated with serious hepatotoxicity and fatal liver injury. The purpose of this study was to examine the hepatoprotector effect of press needle acupuncture on drug induced liver injury caused by INH and rifampicin by measuring the histopathological changes and variations in the SGOT, SGPT and MDA levels. This single-blinded, experimental, randomised control trial included 28 Wistar rats that were randomly allocated into four groups [control group (n = 7), negative control group (n = 7), press needle group (n = 7) and Sham acupuncture group (n = 7)]. Press needle acupuncture was administered using Pyonex press needle at Acupoints GB34 Yanglingquan and BL18 Ganshu. Significant differences in the mean histopathological scores were observed between the groups. The press needle acupuncture group exhibited lower steatosis (1.57 ± 0.787) compared to the negative control (2.33 ± 0.516) and the Sham acupuncture groups (2.29 ± 0.488) (p < 0.05). Therefore, it was concluded that press needle acupuncture had a hepatoprotector effect on histopathological changes associated with drug induced liver injury caused by isoniazid and rifampicin.

Original languageEnglish
Article number062029
JournalJournal of Physics: Conference Series
Volume1073
Issue number6
DOIs
Publication statusPublished - 7 Sep 2018
Event2nd Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2018 - Depok, West Java, Indonesia
Duration: 18 Jul 201818 Jul 2018

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