Hepatoprotective effect of 50% ethanol extract of seagrass rhizome (Cymodocea Rotundata) against liver tissues in paracetamol-induced rats

Renita Dewi, Raesha Dwina Malika, Ade Mara Meilani, Fadlina Chany Saputri

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to determine the hepatoprotective effect of 50% ethanol extract of seagrass rhizome in terms of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) activities in paracetamol-induced rat plasma. Methods: This study included 28 male, white rats randomly divided into seven groups. Groups I and II represented the normal control and control groups, respectively, administered with 280 mg/kg BW of rhizome extract. Group III represented the negative control group induced by a suspension of paracetamol (2g/kg BW). Group IV represented a positive control group administered with Hepa-Q® at a dosage of 150 mg/kg BW. Groups V, VI, and VII were administered with seagrass rhizome extract at doses of 140, 280, and 560 mg/kg BW, respectively, before paracetamol induction. The test material was orally administered for 17 days. On days 12-17, the rats were induced with paracetamol through the same route. On day 18, blood sampling was performed followed by SGOT and SGPT plasma measurements. Results: Our results revealed that seagrass rhizome extracts could significantly decrease SGPT and SGOT levels in paracetamol-induced rats (p<0.05) compared with those in the negative control group. Conclusion: Thus, seagrass rhizome extracts possess the potential for development as a hepatoprotective agent.

Original languageEnglish
Pages (from-to)240-242
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Hepatoprotective
  • Paracetamol
  • Seagrass rhizome
  • Serum glutamic oxaloacetic transaminase
  • Serum glutamic pyruvic transaminase

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