TY - JOUR
T1 - Hepatitis C virus genotypes and co-infection with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia
AU - Lesmana, Laurentius M. Adrianto
AU - Sulaiman, H. Ali
AU - Noer, H. M.Sjaifoellah
AU - Tsuda, Fumio
AU - Okamoto, Hiroaki
PY - 1996/11
Y1 - 1996/11
N2 - Of 153 patients with chronic liver disease in Jakarta, Indonesia, who were positive for antibody to hepatitis C virus (HCV), 129 (84%) had HCV RNA in serum. HCV genotypes were II/1b in 55 (43%), III/2a in 33 (26%) and 1c in 15 (12%) patients; genotypes were not classifiable into the common five (I/1a, II/1b, III/2a, IV/2b and V/3a) or 1c in the remaining 25 (19%) patients. RNA of a putative non-A-E hepatitis virus, designated GB virus C (GBV-C), was tested for by reverse-transcription polymerase chain reaction with nested primers deduced from the 5'-noncoding region, and detected in 18 (12%) patients of whom 14 (78%) possessed serum HCV RNA. These results indicate that 1c and the other indigenous genotypes of HCV, as well as the co-infection with GBV-C, would be common among Indonesian patients with HCV-associated chronic liver disease.
AB - Of 153 patients with chronic liver disease in Jakarta, Indonesia, who were positive for antibody to hepatitis C virus (HCV), 129 (84%) had HCV RNA in serum. HCV genotypes were II/1b in 55 (43%), III/2a in 33 (26%) and 1c in 15 (12%) patients; genotypes were not classifiable into the common five (I/1a, II/1b, III/2a, IV/2b and V/3a) or 1c in the remaining 25 (19%) patients. RNA of a putative non-A-E hepatitis virus, designated GB virus C (GBV-C), was tested for by reverse-transcription polymerase chain reaction with nested primers deduced from the 5'-noncoding region, and detected in 18 (12%) patients of whom 14 (78%) possessed serum HCV RNA. These results indicate that 1c and the other indigenous genotypes of HCV, as well as the co-infection with GBV-C, would be common among Indonesian patients with HCV-associated chronic liver disease.
KW - chronic hepatitis
KW - cirrhosis
KW - genotypes
KW - hepatitis C
KW - hepatitis viruses
UR - http://www.scopus.com/inward/record.url?scp=0030297998&partnerID=8YFLogxK
U2 - 10.1016/S0928-4346(96)00321-0
DO - 10.1016/S0928-4346(96)00321-0
M3 - Article
AN - SCOPUS:0030297998
SN - 0928-4346
VL - 6
SP - 16
EP - 23
JO - International Hepatology Communications
JF - International Hepatology Communications
IS - 1
ER -