Hepatitis C virus genotypes and co-infection with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia

Laurentius M. Adrianto Lesmana, H. Ali Sulaiman, H. M.Sjaifoellah Noer, Fumio Tsuda, Hiroaki Okamoto

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3 Citations (Scopus)

Abstract

Of 153 patients with chronic liver disease in Jakarta, Indonesia, who were positive for antibody to hepatitis C virus (HCV), 129 (84%) had HCV RNA in serum. HCV genotypes were II/1b in 55 (43%), III/2a in 33 (26%) and 1c in 15 (12%) patients; genotypes were not classifiable into the common five (I/1a, II/1b, III/2a, IV/2b and V/3a) or 1c in the remaining 25 (19%) patients. RNA of a putative non-A-E hepatitis virus, designated GB virus C (GBV-C), was tested for by reverse-transcription polymerase chain reaction with nested primers deduced from the 5'-noncoding region, and detected in 18 (12%) patients of whom 14 (78%) possessed serum HCV RNA. These results indicate that 1c and the other indigenous genotypes of HCV, as well as the co-infection with GBV-C, would be common among Indonesian patients with HCV-associated chronic liver disease.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalInternational Hepatology Communications
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Nov 1996

Keywords

  • chronic hepatitis
  • cirrhosis
  • genotypes
  • hepatitis C
  • hepatitis viruses

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