TY - JOUR
T1 - Hepatitis C virus genotype in blood donors and associated liver disease in indonesia
AU - Utama, Andi
AU - Budiarto, Bugi Ratno
AU - Monasari, Dewi
AU - Octavia, Theresia Imelda
AU - Chandra, Ivan Stevanus
AU - Gani, Rino A.
AU - Hasan, Irsan
AU - Sanityoso, Andri
AU - Miskad, Upik Anderiani
AU - Yusuf, Irawan
AU - Lesmana, Laurentius M. Adrianto
AU - Sulaiman, Ali
AU - Tai, Susan
PY - 2009/4
Y1 - 2009/4
N2 - Objective: The aim of this study was to investigate the distribution of hepatitis C virus (HCV) genotype and the possible association between genotype and HCV-associated liver disease in Indonesia. Methods: 32 anti-HCV-positive asymptomatic carriers (AC), 55 chronic hepatitis (CH), 41 liver cirrhosis (LC), and 35 hepatocellular carcinoma (HCC) patients were included in this study. HCV genotyping was performed by phylogenetic analysis of the NS5B and 5′-UTR regions. Results: The HCV subtype 1b (36.5%), based on NS5B region, was the most prevalent, followed by subtypes 3k (15.4%), 2a (14.4%), 1a (12.5%) and 1c (12.5%), and 2e (4.8%). Subtypes 2f, 3a, 3b, and 4a were also found in some of the samples. HCV subtypes 3k (40.0%) and 1a (35.0%) were the two major subtypes in AC. HCV subtype 1b was not found in AC, but it was common in CH (31.3%), LC (50.0%), and HCC (57.1%). Conclusion: HCV subtype 1b was prevalent in samples of HCV-associated liver disease patients, including CH, LC and HCC. The percentage of subtype 1b was increased with the disease severity (AC < CH < LC < HCC).
AB - Objective: The aim of this study was to investigate the distribution of hepatitis C virus (HCV) genotype and the possible association between genotype and HCV-associated liver disease in Indonesia. Methods: 32 anti-HCV-positive asymptomatic carriers (AC), 55 chronic hepatitis (CH), 41 liver cirrhosis (LC), and 35 hepatocellular carcinoma (HCC) patients were included in this study. HCV genotyping was performed by phylogenetic analysis of the NS5B and 5′-UTR regions. Results: The HCV subtype 1b (36.5%), based on NS5B region, was the most prevalent, followed by subtypes 3k (15.4%), 2a (14.4%), 1a (12.5%) and 1c (12.5%), and 2e (4.8%). Subtypes 2f, 3a, 3b, and 4a were also found in some of the samples. HCV subtypes 3k (40.0%) and 1a (35.0%) were the two major subtypes in AC. HCV subtype 1b was not found in AC, but it was common in CH (31.3%), LC (50.0%), and HCC (57.1%). Conclusion: HCV subtype 1b was prevalent in samples of HCV-associated liver disease patients, including CH, LC and HCC. The percentage of subtype 1b was increased with the disease severity (AC < CH < LC < HCC).
KW - Chronic hepatitis C
KW - Genotype
KW - Hepatitis C virus
KW - Hepatocellular carcinoma
KW - Indonesia
KW - Liver cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=61349087361&partnerID=8YFLogxK
U2 - 10.1159/000205515
DO - 10.1159/000205515
M3 - Article
C2 - 19258720
AN - SCOPUS:61349087361
SN - 0300-5526
VL - 51
SP - 410
EP - 416
JO - Intervirology
JF - Intervirology
IS - 6
ER -
