Hepatitis C virus genotype in blood donors and associated liver disease in indonesia

Andi Utama, Bugi Ratno Budiarto, Dewi Monasari, Theresia Imelda Octavia, Ivan Stevanus Chandra, Rino A. Gani, Irsan Hasan, Andri Sanityoso, Upik Anderiani Miskad, Irawan Yusuf, Laurentius M. Adrianto Lesmana, Ali Sulaiman, Susan Tai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Objective: The aim of this study was to investigate the distribution of hepatitis C virus (HCV) genotype and the possible association between genotype and HCV-associated liver disease in Indonesia. Methods: 32 anti-HCV-positive asymptomatic carriers (AC), 55 chronic hepatitis (CH), 41 liver cirrhosis (LC), and 35 hepatocellular carcinoma (HCC) patients were included in this study. HCV genotyping was performed by phylogenetic analysis of the NS5B and 5′-UTR regions. Results: The HCV subtype 1b (36.5%), based on NS5B region, was the most prevalent, followed by subtypes 3k (15.4%), 2a (14.4%), 1a (12.5%) and 1c (12.5%), and 2e (4.8%). Subtypes 2f, 3a, 3b, and 4a were also found in some of the samples. HCV subtypes 3k (40.0%) and 1a (35.0%) were the two major subtypes in AC. HCV subtype 1b was not found in AC, but it was common in CH (31.3%), LC (50.0%), and HCC (57.1%). Conclusion: HCV subtype 1b was prevalent in samples of HCV-associated liver disease patients, including CH, LC and HCC. The percentage of subtype 1b was increased with the disease severity (AC < CH < LC < HCC).

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalIntervirology
Volume51
Issue number6
DOIs
Publication statusPublished - 1 Apr 2009

Keywords

  • Chronic hepatitis C
  • Genotype
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Indonesia
  • Liver cirrhosis

Fingerprint Dive into the research topics of 'Hepatitis C virus genotype in blood donors and associated liver disease in indonesia'. Together they form a unique fingerprint.

Cite this