Hepatitis C vims RNA detection and HCV genotype in patients with chronic non-A, non-B hepatitis in Jakarta

Suwandhi Widjaja; Sheng Li; Sugianto All; Sumanto Simon; Ali Sulaiman; Laurentius M. Adrianto Lesmana; Sing Hiem Yapc

doi:10.1016/0166-0934(94)00101-L

Hepatitis C vims RNA detection and HCV genotype in patients with chronic non-A, non-B hepatitis in Jakarta

Suwandhi Widjaja, Sheng Li, Sugianto All, Sumanto Simon, Ali Sulaiman, Laurentius M. Adrianto Lesmana, Sing Hiem Yapc

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Antibody response in HCV infection may be variable and the variability of the serological response could be due to the differences in HCV strains. Since the distribution of hepatitis C virus genotype has been found to be geographically dependent, it is important to determine the distribution of HCV genotype in various countries with high prevalence of chronic non-A, non-B hepatitis. In this study, serum HCV RNA was examined in 53 patients suspected of chronic non-A, non-B hepatitis with an anti-HCV test as determined by currently available assay. HCV viremia was detected in 48 patients (90.6%). These patients had elevated serum ALT level at the time of HCV RNA determination. Using specific genotype probes, all isolates were classified into three different genotypes. Double and triple infections were also noted. HCV genotype Ib is the predominant genotype found in chronic hepatitis C patients in Jakarta.

Original language	English
Pages (from-to)	169-175
Number of pages	7
Journal	Journal of Virological Methods
Volume	51
Issue number	2-3
DOIs	https://doi.org/10.1016/0166-0934(94)00101-L
Publication status	Published - Feb 1995

Keywords

HCV RNA
HCV genotype
Hepatitis C
Polymerase chain reaction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0166-0934(94)00101-L

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@article{6b1a21046655416da175261c1367d093,

title = "Hepatitis C vims RNA detection and HCV genotype in patients with chronic non-A, non-B hepatitis in Jakarta",

abstract = "Antibody response in HCV infection may be variable and the variability of the serological response could be due to the differences in HCV strains. Since the distribution of hepatitis C virus genotype has been found to be geographically dependent, it is important to determine the distribution of HCV genotype in various countries with high prevalence of chronic non-A, non-B hepatitis. In this study, serum HCV RNA was examined in 53 patients suspected of chronic non-A, non-B hepatitis with an anti-HCV test as determined by currently available assay. HCV viremia was detected in 48 patients (90.6%). These patients had elevated serum ALT level at the time of HCV RNA determination. Using specific genotype probes, all isolates were classified into three different genotypes. Double and triple infections were also noted. HCV genotype Ib is the predominant genotype found in chronic hepatitis C patients in Jakarta.",

keywords = "HCV RNA, HCV genotype, Hepatitis C, Polymerase chain reaction",

author = "Suwandhi Widjaja and Sheng Li and Sugianto All and Sumanto Simon and Ali Sulaiman and Lesmana, {Laurentius M. Adrianto} and Yapc, {Sing Hiem}",

note = "Funding Information: This work was supportedi n part by a grant from A.B.O.S. Ontwikkelings Samenwerking).",

year = "1995",

month = feb,

doi = "10.1016/0166-0934(94)00101-L",

language = "English",

volume = "51",

pages = "169--175",

journal = "Journal of Virological Methods",

issn = "0166-0934",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - Hepatitis C vims RNA detection and HCV genotype in patients with chronic non-A, non-B hepatitis in Jakarta

AU - Widjaja, Suwandhi

AU - Li, Sheng

AU - All, Sugianto

AU - Simon, Sumanto

AU - Sulaiman, Ali

AU - Lesmana, Laurentius M. Adrianto

AU - Yapc, Sing Hiem

N1 - Funding Information: This work was supportedi n part by a grant from A.B.O.S. Ontwikkelings Samenwerking).

PY - 1995/2

Y1 - 1995/2

N2 - Antibody response in HCV infection may be variable and the variability of the serological response could be due to the differences in HCV strains. Since the distribution of hepatitis C virus genotype has been found to be geographically dependent, it is important to determine the distribution of HCV genotype in various countries with high prevalence of chronic non-A, non-B hepatitis. In this study, serum HCV RNA was examined in 53 patients suspected of chronic non-A, non-B hepatitis with an anti-HCV test as determined by currently available assay. HCV viremia was detected in 48 patients (90.6%). These patients had elevated serum ALT level at the time of HCV RNA determination. Using specific genotype probes, all isolates were classified into three different genotypes. Double and triple infections were also noted. HCV genotype Ib is the predominant genotype found in chronic hepatitis C patients in Jakarta.

AB - Antibody response in HCV infection may be variable and the variability of the serological response could be due to the differences in HCV strains. Since the distribution of hepatitis C virus genotype has been found to be geographically dependent, it is important to determine the distribution of HCV genotype in various countries with high prevalence of chronic non-A, non-B hepatitis. In this study, serum HCV RNA was examined in 53 patients suspected of chronic non-A, non-B hepatitis with an anti-HCV test as determined by currently available assay. HCV viremia was detected in 48 patients (90.6%). These patients had elevated serum ALT level at the time of HCV RNA determination. Using specific genotype probes, all isolates were classified into three different genotypes. Double and triple infections were also noted. HCV genotype Ib is the predominant genotype found in chronic hepatitis C patients in Jakarta.

KW - HCV RNA

KW - HCV genotype

KW - Hepatitis C

KW - Polymerase chain reaction

UR - http://www.scopus.com/inward/record.url?scp=0028891083&partnerID=8YFLogxK

U2 - 10.1016/0166-0934(94)00101-L

DO - 10.1016/0166-0934(94)00101-L

M3 - Article

C2 - 7738137

AN - SCOPUS:0028891083

SN - 0166-0934

VL - 51

SP - 169

EP - 175

JO - Journal of Virological Methods

JF - Journal of Virological Methods

IS - 2-3

ER -

Hepatitis C vims RNA detection and HCV genotype in patients with chronic non-A, non-B hepatitis in Jakarta

Abstract

Keywords

UN SDGs

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